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Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity

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Author(s)

  • Yanning Ding
  • William J. Brackenbury
  • Pinar U. Onganer
  • Ximena Montano
  • Louise M. Porter
  • Lucy F. Bates
  • Mustafa B. A. Djamgoz

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Publication details

JournalJournal of cellular physiology
DateE-pub ahead of print - 24 Oct 2007
DatePublished (current) - Apr 2008
Issue number1
Volume215
Number of pages5
Pages (from-to)77-81
Early online date24/10/07
Original languageEnglish

Abstract

The main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage-gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells. Incubation with EGF for 24 h more than doubled VGSC current density. Similar treatment with EGF significantly and dose-dependently enhanced the cells' migration through Transwell filters. Both the patch clamp recordings and the migration assay suggested that endogenous EGF played a similar role. Importantly, co-application of EGF and tetrodotoxin, a highly selective VGSC blocker, abolished 65% of the potentiating effect of EGF. It is suggested that a significant portion of the EGF-induced enhancement of migration occurred via VGSC activity.

Bibliographical note

Copyright © 2007 Wiley-Liss, Inc. This is an author produced version of a paper published in Journal of Cellular Physiology. Uploaded in accordance with the publisher's self-archiving policy.

    Research areas

  • FACTOR RECEPTOR, BREAST-CANCER, IN-VITRO, METASTATIC CASCADE, SODIUM-CHANNELS, LUNG-CANCER, FUNCTIONAL EXPRESSION, MEMBRANE-ACTIVITY, ELECTRIC-FIELD, LINE

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