eta(4)-Pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)

I J S  Fairlamb; A K  Duhme-Klair; J M  Lynam; B E  Moulton; C T  O'Brien; P  Sawle; J  Hammad; R  Motterlini

doi:10.1016/j.bmcl.2005.10.085

eta(4)-Pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)

I J S Fairlamb, A K Duhme-Klair, J M Lynam, B E Moulton, C T O'Brien, P Sawle, J Hammad, R Motterlini

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (eta(4)-2-pyrone)Fe(CO)(3) Complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications. (c) 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	995-998
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2005.10.085
Publication status	Published - 15 Feb 2006

Keywords

vasorelaxation
carbon monoxide
transiton metal carbonyl complexes
therapeutic agents
CARBON-MONOXIDE
HEME OXYGENASE-1
CHOLESTEROL ESTERASE
IN-VIVO
2-PYRONES
PATHWAY

Access to Document

10.1016/j.bmcl.2005.10.085

Cite this

@article{e3136db65b0e40d482390501bd488910,

title = "eta(4)-Pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)",

abstract = "The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (eta(4)-2-pyrone)Fe(CO)(3) Complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications. (c) 2005 Elsevier Ltd. All rights reserved.",

keywords = "vasorelaxation, carbon monoxide, transiton metal carbonyl complexes, therapeutic agents, CARBON-MONOXIDE, HEME OXYGENASE-1, CHOLESTEROL ESTERASE, IN-VIVO, 2-PYRONES, PATHWAY",

author = "Fairlamb, {I J S} and Duhme-Klair, {A K} and Lynam, {J M} and Moulton, {B E} and O'Brien, {C T} and P Sawle and J Hammad and R Motterlini",

year = "2006",

month = feb,

day = "15",

doi = "10.1016/j.bmcl.2005.10.085",

language = "English",

volume = "16",

pages = "995--998",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier",

number = "4",

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TY - JOUR

T1 - eta(4)-Pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)

AU - Fairlamb, I J S

AU - Duhme-Klair, A K

AU - Lynam, J M

AU - Moulton, B E

AU - O'Brien, C T

AU - Sawle, P

AU - Hammad, J

AU - Motterlini, R

PY - 2006/2/15

Y1 - 2006/2/15

N2 - The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (eta(4)-2-pyrone)Fe(CO)(3) Complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications. (c) 2005 Elsevier Ltd. All rights reserved.

AB - The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (eta(4)-2-pyrone)Fe(CO)(3) Complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications. (c) 2005 Elsevier Ltd. All rights reserved.

KW - vasorelaxation

KW - carbon monoxide

KW - transiton metal carbonyl complexes

KW - therapeutic agents

KW - CARBON-MONOXIDE

KW - HEME OXYGENASE-1

KW - CHOLESTEROL ESTERASE

KW - IN-VIVO

KW - 2-PYRONES

KW - PATHWAY

U2 - 10.1016/j.bmcl.2005.10.085

DO - 10.1016/j.bmcl.2005.10.085

M3 - Article

SN - 0960-894X

VL - 16

SP - 995

EP - 998

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 4

ER -