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eta(4)-Pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)

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JournalBioorganic & Medicinal Chemistry Letters
DatePublished - 15 Feb 2006
Issue number4
Volume16
Number of pages4
Pages (from-to)995-998
Original languageEnglish

Abstract

The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (eta(4)-2-pyrone)Fe(CO)(3) Complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications. (c) 2005 Elsevier Ltd. All rights reserved.

    Research areas

  • vasorelaxation, carbon monoxide, transiton metal carbonyl complexes, therapeutic agents, CARBON-MONOXIDE, HEME OXYGENASE-1, CHOLESTEROL ESTERASE, IN-VIVO, 2-PYRONES, PATHWAY

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