EUROGIN 2011 roadmap on prevention and treatment of HPV-related disease

Marc Arbyn, Silvia de Sanjosé, Mona Saraiya, Mario Sideri, Joel Palefsky, Charles Lacey, Maura Gillison, Laia Bruni, Guglielmo Ronco, Nicolas Wentzensen, Julia Brotherton, You-Lin Qiao, Lynnette Denny, Jacob Bornstein, Laurent Abramowitz, Anna Giuliano, Massimo Tommasino, Joseph Monsonego

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The EUROGIN 2011 roadmap reviews the current burden of HPV (human papillomavirus)-related morbidity, as well as the evidence and potential practice recommendations regarding primary and secondary prevention and treatment of cancers and other disease associated with HPV infection. HPV infection causes approximately 600,000 cases of cancer of the cervix, vulva, vagina, anus and oropharynx annually, as well as benign diseases such as genital warts and recurrent respiratory papillomatosis. Whereas the incidence of cervical cancer has been decreasing over recent decades, the incidence of anal and oropharyngeal carcinoma, for which there are no effective screening programs, has been rising over the last couple of decades. Randomised trials have demonstrated improved efficacy of HPV-based compared to cytology-based cervical cancer screening. Defining the best algorithms to triage HPV-positive women, age ranges and screening intervals are priorities for pooled analyses and further research, whereas feasibility questions can be addressed through screening programmes. HPV vaccination will reduce the burden of cervical precancer and probably also of invasive cervical and other HPV-related disease in women. Recent trials demonstrated that prophylactic vaccination also protects against anogenital HPV infection, ano-genital intraepithelial lesions and warts associated with vaccine types, in males; and anal HPV infection and anal intraepithelial neoplasia in MSM. HPV-related oropharyngeal cancer could be treated less aggressively because of better survival compared to cancers of the oropharynx unrelated to HPV. Key findings in the field of cervical cancer prevention should now be translated in cost-effective strategies, following an organised approach integrating primary and secondary prevention, according to scientific evidence but adapted to the local situation with particular attention to regions with the highest burden of disease.
Original languageEnglish
Pages (from-to)1969-1982
Number of pages14
JournalInternational Journal of Cancer
Issue number9
Publication statusPublished - 1 Nov 2012

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