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The efficiency of l -valine and l -proline nitriles and a tert -butylÂ- l -proline imidate as organocatalysts for the aldol reaction have been evaluated. l -Valine nitrile was found to be a syn -selective catalyst, while l -proline nitrile was found to be anti -selective, and gave products in modest to good enantioselectivities. tert -Butyl l -proline imidate was found to be a very efficient catalyst in terms of conversion of starting reagents to products, and gave good anti -selectivity. The enantioselectivity of the tert -butyl l -proline imidate was found to be good to excellent, with products being formed in up to 94% enantiomeric excess.
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- asymmetric synthesis
- amino imidate
- amino nitrile
- aldol reaction
- 2 Finished
Clarke, P. A., Vagkidis, N. & Sosunovych, B.
1/10/17 → 30/04/22
Project: Other project › Miscellaneous project
Clarke, P. A. (Creator), Sosunovych, B. (Contributor) & Brown, A. (Contributor), University of York, 1 Oct 2021
Clarke, P. A. (Creator), Vagkidis, N. (Contributor) & Brown, A. (Contributor), University of York, 2019