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From the same journal

Evaluation of Amino Nitriles and an Amino Imidate as Organocatalysts in Aldol Reactions

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JournalSYNTHESIS-STUTTGART
DateAccepted/In press - 18 Jul 2019
DateE-pub ahead of print (current) - 8 Aug 2019
Issue number21
Volume51
Number of pages7
Pages (from-to)4106-4112
Early online date8/08/19
Original languageEnglish

Abstract

The efficiency of l -valine and l -proline nitriles and a tert -butylÂ- l -proline imidate as organocatalysts for the aldol reaction have been evaluated. l -Valine nitrile was found to be a syn -selective catalyst, while l -proline nitrile was found to be anti -selective, and gave products in modest to good enantioselectivities. tert -Butyl l -proline imidate was found to be a very efficient catalyst in terms of conversion of starting reagents to products, and gave good anti -selectivity. The enantioselectivity of the tert -butyl l -proline imidate was found to be good to excellent, with products being formed in up to 94% enantiomeric excess.

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    Research areas

  • asymmetric synthesis, organocatalysis, amino imidate, amino nitrile, aldol reaction

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