By the same authors

From the same journal

Evaluation of Amino Nitriles and an Amino Imidate as Organocatalysts in Aldol Reactions

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JournalSYNTHESIS-STUTTGART
DateAccepted/In press - 18 Jul 2019
DateE-pub ahead of print (current) - 8 Aug 2019
Volume51
Number of pages7
Early online date8/08/19
Original languageEnglish

Abstract

The efficiency of L-valine and L-proline nitriles and a tertbutyl
L-proline imidate as organocatalysts for the aldol reaction have
been evaluated. L-Valine nitrile was found to be a syn-selective catalyst,
while L-proline nitrile was found to be anti-selective, and gave products
in modest to good enantioselectivities. tert-Butyl L-proline imidate was
found to be a very efficient catalyst in terms of conversion of starting
reagents to products, and gave good anti-selectivity. The enantioselectivity
of the tert-butyl L-proline imidate was found to be good to excellent,
with products being formed in up to 94% enantiomeric excess.

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    Research areas

  • asymmetric synthesis, organocatalysis, amino imidate, amino nitrile, aldol reaction

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