By the same authors

From the same journal

Evaluation of Amino Nitriles and an Amino Imidate as Organocatalysts in Aldol Reactions

Research output: Contribution to journalArticlepeer-review



Publication details

DateAccepted/In press - 18 Jul 2019
DatePublished (current) - 8 Aug 2019
Issue number21
Number of pages7
Pages (from-to)4106-4112
Original languageEnglish


The efficiency of l -valine and l -proline nitriles and a tert -butylÂ- l -proline imidate as organocatalysts for the aldol reaction have been evaluated. l -Valine nitrile was found to be a syn -selective catalyst, while l -proline nitrile was found to be anti -selective, and gave products in modest to good enantioselectivities. tert -Butyl l -proline imidate was found to be a very efficient catalyst in terms of conversion of starting reagents to products, and gave good anti -selectivity. The enantioselectivity of the tert -butyl l -proline imidate was found to be good to excellent, with products being formed in up to 94% enantiomeric excess.

Bibliographical note

© 2019. Thieme. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

    Research areas

  • asymmetric synthesis, organocatalysis, amino imidate, amino nitrile, aldol reaction

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations