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Evolving classifiers to recognize the movement characteristics of Parkinson’s Disease patients

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JournalIEEE Transactions on Evolutionary Computation
DateE-pub ahead of print - 16 Sep 2013
DatePublished (current) - Aug 2014
Issue number4
Volume18
Number of pages18
Pages (from-to)559-576
Early online date16/09/13
Original languageEnglish

Abstract

Parkinson’s disease is a debilitating neurological condition that affects approximately 1 in 500 people and often leads to severe disability. To improve clinical care, better assessment tools are needed that increase the accuracy of differential diagnosis and disease monitoring. In this paper, we report how we have used evolutionary algorithms to induce classifiers capable of recognising the movement characteristics of Parkinson’s disease patients. These diagnostically-relevant patterns of movement are known to occur over multiple time scales. To capture this, we used two different classifier architectures: sliding-window genetic programming classifiers, which model over-represented local patterns that occur within time series data, and artificial biochemical networks, computational dynamical systems that respond to dynamical patterns occurring over longer time scales. Classifiers were trained and validated using movement recordings of 49 patients and 41 age-matched controls collected during a recent clinical study. By combining classifiers with diverse behaviours, we were able to construct classifier ensembles with diagnostic accuracies in the region of 95%, comparable to the accuracies achieved by expert clinicians. Further analysis indicated a number of features of diagnostic relevance, including the differential effect of handedness and the over-representation of certain patterns of acceleration.

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