By the same authors

From the same journal

Expedient Synthesis, on Large Scale, of Aliphatic Chaetomellic Anhydrides from N-Allyl-2,2-dichlorocarboxyamides

Research output: Contribution to journalArticle

Published copy (DOI)

Author(s)

  • Franco Ghelfi
  • Mariella Pattarozzi
  • Fabrizio Roncaglia
  • Valerio Giangiordano
  • Andrew F. Parsons

Department/unit(s)

Publication details

JournalSYNTHETIC COMMUNICATIONS
DatePublished - Jan 2010
Issue number7
Volume40
Number of pages12
Pages (from-to)1040-1051
Original languageEnglish

Abstract

Chaetomellic anhydride A and an analog (with two additional carbons) were obtained, on a preparative scale, starting from amides derived from the acylation of 2-(2-propenylamino)pyridine with 2,2-dichloropalmitic or 2,2-dichlorostearic acid. An alternative approach, in which the methyl substituent of the target anhydride is introduced by the carboxylic acid reactant and the long aliphatic chain is added through the allylamino moiety, proved unviable.

    Research areas

  • Chaetomellic anhydride, halocompounds, lactams, radical reactions, FARNESYL-PROTEIN TRANSFERASE, FUNCTIONAL REARRANGEMENT, ACIDS, INHIBITORS

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