Experimental and computational insights into the mechanism of the copper(I)-catalysed sulfonylative Suzuki-Miyaura reaction

Helen Sneddon*, Callum Hall, Peter Pogany, David Lindsay, William Kerr*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A mechanistic study into the copper(I)-catalysed sulfonylative Suzuki–Miyaura reaction, incorporating sulfur dioxide, is described. Utilising spectroscopic and computational techniques, an exploration into the individual components of the competing catalytic cycles is delineated, including identification of the resting state catalyst, transmetalation of arylboronic acid onto copper(I), the sulfur dioxide insertion process, and the oxidative addition of aryl halide to CuI. Studies also investigated prominent side-reactions which were uncovered, including a competing copper(II)-catalysed mechanism. This led to an additional proposed and connected CuI/CuII/CuIII catalytic cycle to account for by-product formation.
Original languageEnglish
Pages (from-to)6738-6755
Number of pages18
JournalChemical Science
Publication statusPublished - 31 May 2023

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