Activities per year
Abstract
The field of antibacterial siderophore conjugates, referred to as Trojan Horse antibacterials, has received increasing attention in recent years, driven by the rise of antimicrobial resistance. Trojan Horse antibacterials offer an opportunity to exploit the specific pathways present in bacteria for active iron uptake, potentially allowing the drugs to bypass membrane-associated resistance mechanisms. Hence, the Trojan Horse approach might enable the redesigning of old antibiotics and the development of antibacterials that target specific pathogens. Critical parts of evaluating such Trojan Horse antibacterials and improving their design are the quantification of their bacterial uptake and the identification of the pathways by which this occurs. In this minireview, we highlight a selection of the biological and chemical methods used to study the uptake of Trojan Horse antibacterials, exemplified with case studies, some of which have led to drug candidates in clinical development or approved antibiotics.
Original language | English |
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Journal | ChemMedChem |
Early online date | 25 Nov 2020 |
DOIs | |
Publication status | Published - 12 Dec 2020 |
Bibliographical note
© 2020 Wiley‐VCH GmbH. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.-
Gordon Research Conference: Metals in Medicine
Duhme-Klair, A.-K. (Organiser)
26 Jun 2022 → 1 Jul 2022Activity: Participating in or organising an event › Conference
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Exploiting siderophores in the development of antimicrobials and artificial enzymes
Duhme-Klair, A.-K. (Keynote/plenary speaker)
21 May 2021Activity: Talk or presentation › Invited talk
Projects
- 1 Finished
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Siderophores as anchors in artificial metalloenzymes
Duhme-Klair, A.-K. (Principal investigator) & Wilson, K. S. (Co-investigator)
31/12/14 → 30/12/17
Project: Research project (funded) › Research