Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy

Preethi Bala Balakrishnan; Niccolò Silvestri; Tamara Fernandez‐Cabada; Federica  Marinaro; Soraia Fernandes; Sergio Fiorito; Mario Miscuglio; David Serantes; Sergiu Ruta; Karen Livesey; Ondrej Hovorka; Roy William Chantrell; Teresa Pellegrino

doi:10.1002/adma.202003712

Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy

Preethi Bala Balakrishnan, Niccolò Silvestri, Tamara Fernandez‐Cabada, Federica Marinaro, Soraia Fernandes, Sergio Fiorito, Mario Miscuglio, David Serantes, Sergiu Ruta, Karen Livesey, Ondrej Hovorka, Roy William Chantrell, Teresa Pellegrino

Physics

Research output: Contribution to journal › Article › peer-review

Abstract

Nanoparticle‐based magnetic hyperthermia is a well‐known thermal therapy platform studied to treat solid tumors, but its use for monotherapy is limited due to incomplete tumor eradication at hyperthermia temperature (45 °C). It is often combined with chemotherapy for obtaining a more effective therapeutic outcome. Cubic‐shaped cobalt ferrite nanoparticles (Co–Fe NCs) serve as magnetic hyperthermia agents and as a cytotoxic agent due to the known cobalt ion toxicity, allowing the achievement of both heat and cytotoxic effects from a single platform. In addition to this advantage, Co–Fe NCs have the unique ability to form growing chains under an alternating magnetic field (AMF). This unique chain formation, along with the mild hyperthermia and intrinsic cobalt toxicity, leads to complete tumor regression and improved overall survival in an in vivo murine xenograft model, all under clinically approved AMF conditions. Numerical calculations identify magnetic anisotropy as the main Co–Fe NCs’ feature to generate such chain formations. This novel combination therapy can improve the effects of magnetic hyperthermia, inaugurating investigation of mechanical behaviors of nanoparticles under AMF, as a new avenue for cancer therapy.

Original language	English
Article number	2003712
Number of pages	11
Journal	Advanced Materials
Volume	32
Issue number	45
Early online date	1 Oct 2020
DOIs	https://doi.org/10.1002/adma.202003712
Publication status	Published - 10 Oct 2020

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adma.202003712
© 2020 The Authors. Published by Wiley-VCH GmbH.
Final published version, 8.57 MBLicence: CC BY
Balakrishnan et al adma.202003712

Roy William Chantrell
- Physics - Emeritus Professor
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Balakrishnan, P. B., Silvestri, N., Fernandez‐Cabada, T., Marinaro, F., Fernandes, S., Fiorito, S., Miscuglio, M., Serantes, D., Ruta, S., Livesey, K., Hovorka, O., Chantrell, R. W., & Pellegrino, T. (2020). Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy. Advanced Materials, 32(45), Article 2003712. https://doi.org/10.1002/adma.202003712

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title = "Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy",

abstract = "Nanoparticle‐based magnetic hyperthermia is a well‐known thermal therapy platform studied to treat solid tumors, but its use for monotherapy is limited due to incomplete tumor eradication at hyperthermia temperature (45 °C). It is often combined with chemotherapy for obtaining a more effective therapeutic outcome. Cubic‐shaped cobalt ferrite nanoparticles (Co–Fe NCs) serve as magnetic hyperthermia agents and as a cytotoxic agent due to the known cobalt ion toxicity, allowing the achievement of both heat and cytotoxic effects from a single platform. In addition to this advantage, Co–Fe NCs have the unique ability to form growing chains under an alternating magnetic field (AMF). This unique chain formation, along with the mild hyperthermia and intrinsic cobalt toxicity, leads to complete tumor regression and improved overall survival in an in vivo murine xenograft model, all under clinically approved AMF conditions. Numerical calculations identify magnetic anisotropy as the main Co–Fe NCs{\textquoteright} feature to generate such chain formations. This novel combination therapy can improve the effects of magnetic hyperthermia, inaugurating investigation of mechanical behaviors of nanoparticles under AMF, as a new avenue for cancer therapy.",

author = "Balakrishnan, {Preethi Bala} and Niccol{\`o} Silvestri and Tamara Fernandez‐Cabada and Federica Marinaro and Soraia Fernandes and Sergio Fiorito and Mario Miscuglio and David Serantes and Sergiu Ruta and Karen Livesey and Ondrej Hovorka and Chantrell, {Roy William} and Teresa Pellegrino",

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doi = "10.1002/adma.202003712",

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Balakrishnan, PB, Silvestri, N, Fernandez‐Cabada, T, Marinaro, F, Fernandes, S, Fiorito, S, Miscuglio, M, Serantes, D, Ruta, S, Livesey, K, Hovorka, O, Chantrell, RW & Pellegrino, T 2020, 'Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy', Advanced Materials, vol. 32, no. 45, 2003712. https://doi.org/10.1002/adma.202003712

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T1 - Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy

AU - Balakrishnan, Preethi Bala

AU - Silvestri, Niccolò

AU - Fernandez‐Cabada, Tamara

AU - Marinaro, Federica

AU - Fernandes, Soraia

AU - Fiorito, Sergio

AU - Miscuglio, Mario

AU - Serantes, David

AU - Ruta, Sergiu

AU - Livesey, Karen

AU - Hovorka, Ondrej

AU - Chantrell, Roy William

AU - Pellegrino, Teresa

PY - 2020/10/10

Y1 - 2020/10/10

N2 - Nanoparticle‐based magnetic hyperthermia is a well‐known thermal therapy platform studied to treat solid tumors, but its use for monotherapy is limited due to incomplete tumor eradication at hyperthermia temperature (45 °C). It is often combined with chemotherapy for obtaining a more effective therapeutic outcome. Cubic‐shaped cobalt ferrite nanoparticles (Co–Fe NCs) serve as magnetic hyperthermia agents and as a cytotoxic agent due to the known cobalt ion toxicity, allowing the achievement of both heat and cytotoxic effects from a single platform. In addition to this advantage, Co–Fe NCs have the unique ability to form growing chains under an alternating magnetic field (AMF). This unique chain formation, along with the mild hyperthermia and intrinsic cobalt toxicity, leads to complete tumor regression and improved overall survival in an in vivo murine xenograft model, all under clinically approved AMF conditions. Numerical calculations identify magnetic anisotropy as the main Co–Fe NCs’ feature to generate such chain formations. This novel combination therapy can improve the effects of magnetic hyperthermia, inaugurating investigation of mechanical behaviors of nanoparticles under AMF, as a new avenue for cancer therapy.

AB - Nanoparticle‐based magnetic hyperthermia is a well‐known thermal therapy platform studied to treat solid tumors, but its use for monotherapy is limited due to incomplete tumor eradication at hyperthermia temperature (45 °C). It is often combined with chemotherapy for obtaining a more effective therapeutic outcome. Cubic‐shaped cobalt ferrite nanoparticles (Co–Fe NCs) serve as magnetic hyperthermia agents and as a cytotoxic agent due to the known cobalt ion toxicity, allowing the achievement of both heat and cytotoxic effects from a single platform. In addition to this advantage, Co–Fe NCs have the unique ability to form growing chains under an alternating magnetic field (AMF). This unique chain formation, along with the mild hyperthermia and intrinsic cobalt toxicity, leads to complete tumor regression and improved overall survival in an in vivo murine xenograft model, all under clinically approved AMF conditions. Numerical calculations identify magnetic anisotropy as the main Co–Fe NCs’ feature to generate such chain formations. This novel combination therapy can improve the effects of magnetic hyperthermia, inaugurating investigation of mechanical behaviors of nanoparticles under AMF, as a new avenue for cancer therapy.

U2 - 10.1002/adma.202003712

DO - 10.1002/adma.202003712

M3 - Article

SN - 0935-9648

VL - 32

JO - Advanced Materials

JF - Advanced Materials

IS - 45

M1 - 2003712

ER -

Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy

Abstract

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Roy William Chantrell

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