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Exploring the hyperpolarisation of EGTA-based ligands using SABRE

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Exploring the hyperpolarisation of EGTA-based ligands using SABRE. / Tickner, Benjamin; Borozdina, Yulia ; Duckett, Simon B.; Angelovski, Goran.

In: Dalton Transactions, 22.01.2021, p. 1-15.

Research output: Contribution to journalArticlepeer-review

Harvard

Tickner, B, Borozdina, Y, Duckett, SB & Angelovski, G 2021, 'Exploring the hyperpolarisation of EGTA-based ligands using SABRE', Dalton Transactions, pp. 1-15. https://doi.org/10.1039/d0dt03839c

APA

Tickner, B., Borozdina, Y., Duckett, S. B., & Angelovski, G. (2021). Exploring the hyperpolarisation of EGTA-based ligands using SABRE. Dalton Transactions, 1-15. https://doi.org/10.1039/d0dt03839c

Vancouver

Tickner B, Borozdina Y, Duckett SB, Angelovski G. Exploring the hyperpolarisation of EGTA-based ligands using SABRE. Dalton Transactions. 2021 Jan 22;1-15. https://doi.org/10.1039/d0dt03839c

Author

Tickner, Benjamin ; Borozdina, Yulia ; Duckett, Simon B. ; Angelovski, Goran. / Exploring the hyperpolarisation of EGTA-based ligands using SABRE. In: Dalton Transactions. 2021 ; pp. 1-15.

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@article{6fd7df29e92e4bf69d79a3daec89f0c1,
title = "Exploring the hyperpolarisation of EGTA-based ligands using SABRE",
abstract = "The design of molecules whose magnetic resonance (MR) signals report on their biological environment is receiving attention as a route to non-invasive functional MR. Hyperpolarisation techniques improve the sensitivity of MR and enable real time low concentration MR imaging, allowing for the development of novel functional imaging methodologies. In this work, we report on the synthesis of a series of EGTAderived molecules (EGTA – ethylene glycol-bis(2-aminoethylether)-N,N,N{\textquoteright},N{\textquoteright}-tetraacetic acid), whose core structures are known to bind biologically relevant metal ions in vivo, in addition to pyridyl rings that allow reversible ligation to an iridium dihydride complex. Consequently, they are amenable to hyperpolarisation through the parahydrogen-based signal amplification by reversible exchange (SABRE) process. We investigate how the proximity of EGTA and pyridine units, and the identity of the linker group, affect the SABRE hyperpolarisation attained for each agent. We also describe the effect of catalyst identity and coligand presence on these measurements and can achieve 1H NMR signal enhancements of up to 160-fold. We rationalise these results to suggest the design elements needed for probes amenable to SABRE hyperpolarisation whose MR signals might in the future report on the presence of metal ions.",
author = "Benjamin Tickner and Yulia Borozdina and Duckett, {Simon B.} and Goran Angelovski",
note = "{\textcopyright} The Royal Society of Chemistry 2021",
year = "2021",
month = jan,
day = "22",
doi = "10.1039/d0dt03839c",
language = "English",
pages = "1--15",
journal = "Dalton Transactions",
issn = "1477-9234",
publisher = "Royal Society of Chemistry",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Exploring the hyperpolarisation of EGTA-based ligands using SABRE

AU - Tickner, Benjamin

AU - Borozdina, Yulia

AU - Duckett, Simon B.

AU - Angelovski, Goran

N1 - © The Royal Society of Chemistry 2021

PY - 2021/1/22

Y1 - 2021/1/22

N2 - The design of molecules whose magnetic resonance (MR) signals report on their biological environment is receiving attention as a route to non-invasive functional MR. Hyperpolarisation techniques improve the sensitivity of MR and enable real time low concentration MR imaging, allowing for the development of novel functional imaging methodologies. In this work, we report on the synthesis of a series of EGTAderived molecules (EGTA – ethylene glycol-bis(2-aminoethylether)-N,N,N’,N’-tetraacetic acid), whose core structures are known to bind biologically relevant metal ions in vivo, in addition to pyridyl rings that allow reversible ligation to an iridium dihydride complex. Consequently, they are amenable to hyperpolarisation through the parahydrogen-based signal amplification by reversible exchange (SABRE) process. We investigate how the proximity of EGTA and pyridine units, and the identity of the linker group, affect the SABRE hyperpolarisation attained for each agent. We also describe the effect of catalyst identity and coligand presence on these measurements and can achieve 1H NMR signal enhancements of up to 160-fold. We rationalise these results to suggest the design elements needed for probes amenable to SABRE hyperpolarisation whose MR signals might in the future report on the presence of metal ions.

AB - The design of molecules whose magnetic resonance (MR) signals report on their biological environment is receiving attention as a route to non-invasive functional MR. Hyperpolarisation techniques improve the sensitivity of MR and enable real time low concentration MR imaging, allowing for the development of novel functional imaging methodologies. In this work, we report on the synthesis of a series of EGTAderived molecules (EGTA – ethylene glycol-bis(2-aminoethylether)-N,N,N’,N’-tetraacetic acid), whose core structures are known to bind biologically relevant metal ions in vivo, in addition to pyridyl rings that allow reversible ligation to an iridium dihydride complex. Consequently, they are amenable to hyperpolarisation through the parahydrogen-based signal amplification by reversible exchange (SABRE) process. We investigate how the proximity of EGTA and pyridine units, and the identity of the linker group, affect the SABRE hyperpolarisation attained for each agent. We also describe the effect of catalyst identity and coligand presence on these measurements and can achieve 1H NMR signal enhancements of up to 160-fold. We rationalise these results to suggest the design elements needed for probes amenable to SABRE hyperpolarisation whose MR signals might in the future report on the presence of metal ions.

U2 - 10.1039/d0dt03839c

DO - 10.1039/d0dt03839c

M3 - Article

SP - 1

EP - 15

JO - Dalton Transactions

JF - Dalton Transactions

SN - 1477-9234

ER -