Extending the Scope of 19F Hyperpolarization through Signal Amplification by Reversible Exchange in MRI and NMR Spectroscopy

Alexandra M. Olaru, Thomas B.R. Robertson, Jennifer S. Lewis, Alex Antony, Wissam Iali, Ryan E. Mewis*, Simon B. Duckett

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Fluorinated ligands have a variety of uses in chemistry and industry, but it is their medical applications as 18F-labelled positron emission tomography (PET) tracers where they are most visible. In this work, we illustrate the potential of using 19F-containing ligands as future magnetic resonance imaging (MRI) contrast agents and as probes in magnetic resonance spectroscopy studies by significantly increasing their magnetic resonance detectability through the signal amplification by reversible exchange (SABRE) hyperpolarization method. We achieve 19F SABRE polarization in a wide range of molecules, including those essential to medication, and analyze how their steric bulk, the substrate loading, polarization transfer field, pH, and rate of ligand exchange impact the efficiency of SABRE. We conclude by presenting 19F MRI results in phantoms, which demonstrate that many of these agents show great promise as future 19F MRI contrast agents for diagnostic investigations.

Original languageEnglish
Pages (from-to)97-105
Number of pages9
Issue number1
Publication statusPublished - 1 Jan 2018

Bibliographical note

© 2018, The Authors.


  • F NMR spectroscopy
  • hyperpolarization
  • insensitive nuclei enhanced by polarization transfer (INEPT)
  • magnetic resonance imaging (MRI)
  • signal amplification by reversible exchange (SABRE)

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