Extracorporeal Membrane Oxygenation-Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy

Aseervatham Anusha Amali; Sharada Ravikumar; Wei Leong Chew; Zhaohong Tan; Qi Hui Sam; Kaiwen W Chen; Dave Boucher; Graeme MacLaren; Louis Yi Ann Chai

doi:10.1093/cid/ciad517

Extracorporeal Membrane Oxygenation-Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy

Aseervatham Anusha Amali, Sharada Ravikumar, Wei Leong Chew, Zhaohong Tan, Qi Hui Sam, Kaiwen W Chen, Dave Boucher, Graeme MacLaren, Louis Yi Ann Chai

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in the setting of severe pneumonia and abscess-forming melioidosis in an overtly healthy host failing to clear Burkholderia pseudomallei infection, and how targeted adjunctive biological therapy led to a successful outcome.

Original language	English
Pages (from-to)	94-97
Number of pages	4
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume	78
Issue number	1
Early online date	20 Sept 2023
DOIs	https://doi.org/10.1093/cid/ciad517
Publication status	Published - 15 Jan 2024

Bibliographical note

Keywords

Humans
Melioidosis/drug therapy
Burkholderia pseudomallei/genetics
Interferon-gamma/genetics
Extracorporeal Membrane Oxygenation
Mutation

Access to Document

10.1093/cid/ciad517

Cite this

Amali, A. A., Ravikumar, S., Chew, W. L., Tan, Z., Sam, Q. H., Chen, K. W., Boucher, D., MacLaren, G., & Chai, L. Y. A. (2024). Extracorporeal Membrane Oxygenation-Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 78(1), 94-97. https://doi.org/10.1093/cid/ciad517

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abstract = "We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in the setting of severe pneumonia and abscess-forming melioidosis in an overtly healthy host failing to clear Burkholderia pseudomallei infection, and how targeted adjunctive biological therapy led to a successful outcome.",

keywords = "Humans, Melioidosis/drug therapy, Burkholderia pseudomallei/genetics, Interferon-gamma/genetics, Extracorporeal Membrane Oxygenation, Mutation",

author = "Amali, {Aseervatham Anusha} and Sharada Ravikumar and Chew, {Wei Leong} and Zhaohong Tan and Sam, {Qi Hui} and Chen, {Kaiwen W} and Dave Boucher and Graeme MacLaren and Chai, {Louis Yi Ann}",

note = "{\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: [email protected].",

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Amali, AA, Ravikumar, S, Chew, WL, Tan, Z, Sam, QH, Chen, KW, Boucher, D, MacLaren, G & Chai, LYA 2024, 'Extracorporeal Membrane Oxygenation-Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 78, no. 1, pp. 94-97. https://doi.org/10.1093/cid/ciad517

Extracorporeal Membrane Oxygenation-Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy. / Amali, Aseervatham Anusha; Ravikumar, Sharada; Chew, Wei Leong et al.
In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 78, No. 1, 15.01.2024, p. 94-97.

Research output: Contribution to journal › Article › peer-review

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