Extremely low-frequency magnetic fields and survival from childhood acute lymphoblastic leukemia: an international follow-up study

J Schüz; K Grell; S Kinsey; M S Linet; M P Link; G Mezei; B H Pollock; E Roman; Y Zhang; M L McBride; C Johansen; C Spix; J Hagihara; A M Saito; J Simpson; L L Robison; J D Dockerty; M Feychting; L Kheifets; K Frederiksen

doi:10.1038/bcj.2012.43

Extremely low-frequency magnetic fields and survival from childhood acute lymphoblastic leukemia: an international follow-up study

J Schüz, K Grell, S Kinsey, M S Linet, M P Link, G Mezei, B H Pollock, E Roman, Y Zhang, M L McBride, C Johansen, C Spix, J Hagihara, A M Saito, J Simpson, L L Robison, J D Dockerty, M Feychting, L Kheifets, K Frederiksen

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A previous US study reported poorer survival in children with acute lymphoblastic leukemia (ALL) exposed to extremely low-frequency magnetic fields (ELF-MF) above 0.3 μT, but based on small numbers. Data from 3073 cases of childhood ALL were pooled from prospective studies conducted in Canada, Denmark, Germany, Japan, UK and US to determine death or relapse up to 10 years from diagnosis. Adjusting for known prognostic factors, we calculated hazard ratios (HRs) and 95% confidence intervals (CI) for overall survival and event-free survival for ELF-MF exposure categories and by 0.1 μT increases. The HRs by 0.1 μT increases were 1.00 (CI, 0.93-1.07) for event-free survival analysis and 1.04 (CI, 0.97-1.11) for overall survival. ALL cases exposed to >0.3 μT did not have a poorer event-free survival (HR=0.76; CI, 0.44-1.33) or overall survival (HR=0.96; CI, 0.49-1.89). HRs varied little by subtype of ALL. In conclusion, ELF-MF exposure has no impact on the survival probability or risk of relapse in children with ALL.

Original language	English
Article number	e98
Pages (from-to)	1-5
Number of pages	5
Journal	Blood Cancer Journal
Volume	2
DOIs	https://doi.org/10.1038/bcj.2012.43
Publication status	Published - 2012

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10.1038/bcj.2012.43

http://www.nature.com/bcj/journal/v2/n12/full/bcj201243a.html

Cite this

Schüz, J., Grell, K., Kinsey, S., Linet, M. S., Link, M. P., Mezei, G., Pollock, B. H., Roman, E., Zhang, Y., McBride, M. L., Johansen, C., Spix, C., Hagihara, J., Saito, A. M., Simpson, J., Robison, L. L., Dockerty, J. D., Feychting, M., Kheifets, L., & Frederiksen, K. (2012). Extremely low-frequency magnetic fields and survival from childhood acute lymphoblastic leukemia: an international follow-up study. Blood Cancer Journal, 2, 1-5. Article e98. https://doi.org/10.1038/bcj.2012.43

@article{81c75dc16b2341938235a6898b63aad5,

title = "Extremely low-frequency magnetic fields and survival from childhood acute lymphoblastic leukemia: an international follow-up study",

abstract = "A previous US study reported poorer survival in children with acute lymphoblastic leukemia (ALL) exposed to extremely low-frequency magnetic fields (ELF-MF) above 0.3 μT, but based on small numbers. Data from 3073 cases of childhood ALL were pooled from prospective studies conducted in Canada, Denmark, Germany, Japan, UK and US to determine death or relapse up to 10 years from diagnosis. Adjusting for known prognostic factors, we calculated hazard ratios (HRs) and 95% confidence intervals (CI) for overall survival and event-free survival for ELF-MF exposure categories and by 0.1 μT increases. The HRs by 0.1 μT increases were 1.00 (CI, 0.93-1.07) for event-free survival analysis and 1.04 (CI, 0.97-1.11) for overall survival. ALL cases exposed to >0.3 μT did not have a poorer event-free survival (HR=0.76; CI, 0.44-1.33) or overall survival (HR=0.96; CI, 0.49-1.89). HRs varied little by subtype of ALL. In conclusion, ELF-MF exposure has no impact on the survival probability or risk of relapse in children with ALL.",

author = "J Sch{\"u}z and K Grell and S Kinsey and Linet, {M S} and Link, {M P} and G Mezei and Pollock, {B H} and E Roman and Y Zhang and McBride, {M L} and C Johansen and C Spix and J Hagihara and Saito, {A M} and J Simpson and Robison, {L L} and Dockerty, {J D} and M Feychting and L Kheifets and K Frederiksen",

year = "2012",

doi = "10.1038/bcj.2012.43",

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Schüz, J, Grell, K, Kinsey, S, Linet, MS, Link, MP, Mezei, G, Pollock, BH, Roman, E, Zhang, Y, McBride, ML, Johansen, C, Spix, C, Hagihara, J, Saito, AM, Simpson, J, Robison, LL, Dockerty, JD, Feychting, M, Kheifets, L & Frederiksen, K 2012, 'Extremely low-frequency magnetic fields and survival from childhood acute lymphoblastic leukemia: an international follow-up study', Blood Cancer Journal, vol. 2, e98, pp. 1-5. https://doi.org/10.1038/bcj.2012.43

TY - JOUR

T1 - Extremely low-frequency magnetic fields and survival from childhood acute lymphoblastic leukemia

T2 - an international follow-up study

AU - Schüz, J

AU - Grell, K

AU - Kinsey, S

AU - Linet, M S

AU - Link, M P

AU - Mezei, G

AU - Pollock, B H

AU - Roman, E

AU - Zhang, Y

AU - McBride, M L

AU - Johansen, C

AU - Spix, C

AU - Hagihara, J

AU - Saito, A M

AU - Simpson, J

AU - Robison, L L

AU - Dockerty, J D

AU - Feychting, M

AU - Kheifets, L

AU - Frederiksen, K

PY - 2012

Y1 - 2012

N2 - A previous US study reported poorer survival in children with acute lymphoblastic leukemia (ALL) exposed to extremely low-frequency magnetic fields (ELF-MF) above 0.3 μT, but based on small numbers. Data from 3073 cases of childhood ALL were pooled from prospective studies conducted in Canada, Denmark, Germany, Japan, UK and US to determine death or relapse up to 10 years from diagnosis. Adjusting for known prognostic factors, we calculated hazard ratios (HRs) and 95% confidence intervals (CI) for overall survival and event-free survival for ELF-MF exposure categories and by 0.1 μT increases. The HRs by 0.1 μT increases were 1.00 (CI, 0.93-1.07) for event-free survival analysis and 1.04 (CI, 0.97-1.11) for overall survival. ALL cases exposed to >0.3 μT did not have a poorer event-free survival (HR=0.76; CI, 0.44-1.33) or overall survival (HR=0.96; CI, 0.49-1.89). HRs varied little by subtype of ALL. In conclusion, ELF-MF exposure has no impact on the survival probability or risk of relapse in children with ALL.

AB - A previous US study reported poorer survival in children with acute lymphoblastic leukemia (ALL) exposed to extremely low-frequency magnetic fields (ELF-MF) above 0.3 μT, but based on small numbers. Data from 3073 cases of childhood ALL were pooled from prospective studies conducted in Canada, Denmark, Germany, Japan, UK and US to determine death or relapse up to 10 years from diagnosis. Adjusting for known prognostic factors, we calculated hazard ratios (HRs) and 95% confidence intervals (CI) for overall survival and event-free survival for ELF-MF exposure categories and by 0.1 μT increases. The HRs by 0.1 μT increases were 1.00 (CI, 0.93-1.07) for event-free survival analysis and 1.04 (CI, 0.97-1.11) for overall survival. ALL cases exposed to >0.3 μT did not have a poorer event-free survival (HR=0.76; CI, 0.44-1.33) or overall survival (HR=0.96; CI, 0.49-1.89). HRs varied little by subtype of ALL. In conclusion, ELF-MF exposure has no impact on the survival probability or risk of relapse in children with ALL.

U2 - 10.1038/bcj.2012.43

DO - 10.1038/bcj.2012.43

M3 - Article

C2 - 23262804

SN - 2044-5385

VL - 2

SP - 1

EP - 5

JO - Blood Cancer Journal

JF - Blood Cancer Journal

M1 - e98

ER -