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Fate and uptake of pharmaceuticals in soil-earthworm systems

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Fate and uptake of pharmaceuticals in soil-earthworm systems. / Carter, L.J.; Garman, C.D.; Ryan, J.; Dowle, A.; Bergström, E.; Thomas-Oates, J.; Boxall, A.B.A.

In: Environmental Science and Technology, Vol. 48, No. 10, 20.05.2014, p. 5955-5963.

Research output: Contribution to journalArticlepeer-review

Harvard

Carter, LJ, Garman, CD, Ryan, J, Dowle, A, Bergström, E, Thomas-Oates, J & Boxall, ABA 2014, 'Fate and uptake of pharmaceuticals in soil-earthworm systems', Environmental Science and Technology, vol. 48, no. 10, pp. 5955-5963. https://doi.org/10.1021/es500567w

APA

Carter, L. J., Garman, C. D., Ryan, J., Dowle, A., Bergström, E., Thomas-Oates, J., & Boxall, A. B. A. (2014). Fate and uptake of pharmaceuticals in soil-earthworm systems. Environmental Science and Technology, 48(10), 5955-5963. https://doi.org/10.1021/es500567w

Vancouver

Carter LJ, Garman CD, Ryan J, Dowle A, Bergström E, Thomas-Oates J et al. Fate and uptake of pharmaceuticals in soil-earthworm systems. Environmental Science and Technology. 2014 May 20;48(10):5955-5963. https://doi.org/10.1021/es500567w

Author

Carter, L.J. ; Garman, C.D. ; Ryan, J. ; Dowle, A. ; Bergström, E. ; Thomas-Oates, J. ; Boxall, A.B.A. / Fate and uptake of pharmaceuticals in soil-earthworm systems. In: Environmental Science and Technology. 2014 ; Vol. 48, No. 10. pp. 5955-5963.

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@article{0e608ffbcc284dffb340dbddf07f3b6f,
title = "Fate and uptake of pharmaceuticals in soil-earthworm systems",
abstract = "Pharmaceuticals present a potential threat to soil organisms, yet our understanding of their fate and uptake in soil systems is limited. This study therefore investigated the fate and uptake of C-labeled carbamazepine, diclofenac, fluoxetine, and orlistat in soil-earthworm systems. Sorption coefficients increased in the order of carbamazepine <diclofenac <fluoxetine <orlistat. Dissipation of C varied by compound, and for orlistat, there was evidence of formation of nonextractable residues. Uptake of C was seen for all compounds. Depuration studies showed complete elimination of C for carbamazepine and fluoxetine treatments and partial elimination for orlistat and diclofenac, with greater than 30% of the C remaining in the tissue at the end of the experiment. Pore-water-based bioconcentration factors (BCFs), based on uptake and elimination of C, increased in the order carbamazepine <diclofenac <fluoxetine and orlistat. Liquid chromatography-tandem mass spectrometry and liquid chromatography-Fourier transform mass spectrometry indicated that the observed uptake in the fluoxetine and carbamazepine treatments was due to the parent compounds but that diclofenac was degraded in the test system so uptake was due to unidentifiable transformation products. Comparison of our data with outputs of quantitative structure-activity relationships for estimating BCFs in worms showed that these models tend to overestimate pharmaceutical BCFs so new models are needed.",
author = "L.J. Carter and C.D. Garman and J. Ryan and A. Dowle and E. Bergstr{\"o}m and J. Thomas-Oates and A.B.A. Boxall",
year = "2014",
month = may,
day = "20",
doi = "10.1021/es500567w",
language = "English",
volume = "48",
pages = "5955--5963",
journal = "Environmental Science and Technology",
issn = "0013-936X",
publisher = "American Chemical Society",
number = "10",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Fate and uptake of pharmaceuticals in soil-earthworm systems

AU - Carter, L.J.

AU - Garman, C.D.

AU - Ryan, J.

AU - Dowle, A.

AU - Bergström, E.

AU - Thomas-Oates, J.

AU - Boxall, A.B.A.

PY - 2014/5/20

Y1 - 2014/5/20

N2 - Pharmaceuticals present a potential threat to soil organisms, yet our understanding of their fate and uptake in soil systems is limited. This study therefore investigated the fate and uptake of C-labeled carbamazepine, diclofenac, fluoxetine, and orlistat in soil-earthworm systems. Sorption coefficients increased in the order of carbamazepine <diclofenac <fluoxetine <orlistat. Dissipation of C varied by compound, and for orlistat, there was evidence of formation of nonextractable residues. Uptake of C was seen for all compounds. Depuration studies showed complete elimination of C for carbamazepine and fluoxetine treatments and partial elimination for orlistat and diclofenac, with greater than 30% of the C remaining in the tissue at the end of the experiment. Pore-water-based bioconcentration factors (BCFs), based on uptake and elimination of C, increased in the order carbamazepine <diclofenac <fluoxetine and orlistat. Liquid chromatography-tandem mass spectrometry and liquid chromatography-Fourier transform mass spectrometry indicated that the observed uptake in the fluoxetine and carbamazepine treatments was due to the parent compounds but that diclofenac was degraded in the test system so uptake was due to unidentifiable transformation products. Comparison of our data with outputs of quantitative structure-activity relationships for estimating BCFs in worms showed that these models tend to overestimate pharmaceutical BCFs so new models are needed.

AB - Pharmaceuticals present a potential threat to soil organisms, yet our understanding of their fate and uptake in soil systems is limited. This study therefore investigated the fate and uptake of C-labeled carbamazepine, diclofenac, fluoxetine, and orlistat in soil-earthworm systems. Sorption coefficients increased in the order of carbamazepine <diclofenac <fluoxetine <orlistat. Dissipation of C varied by compound, and for orlistat, there was evidence of formation of nonextractable residues. Uptake of C was seen for all compounds. Depuration studies showed complete elimination of C for carbamazepine and fluoxetine treatments and partial elimination for orlistat and diclofenac, with greater than 30% of the C remaining in the tissue at the end of the experiment. Pore-water-based bioconcentration factors (BCFs), based on uptake and elimination of C, increased in the order carbamazepine <diclofenac <fluoxetine and orlistat. Liquid chromatography-tandem mass spectrometry and liquid chromatography-Fourier transform mass spectrometry indicated that the observed uptake in the fluoxetine and carbamazepine treatments was due to the parent compounds but that diclofenac was degraded in the test system so uptake was due to unidentifiable transformation products. Comparison of our data with outputs of quantitative structure-activity relationships for estimating BCFs in worms showed that these models tend to overestimate pharmaceutical BCFs so new models are needed.

UR - http://www.scopus.com/inward/record.url?scp=84901044559&partnerID=8YFLogxK

U2 - 10.1021/es500567w

DO - 10.1021/es500567w

M3 - Article

AN - SCOPUS:84901044559

VL - 48

SP - 5955

EP - 5963

JO - Environmental Science and Technology

JF - Environmental Science and Technology

SN - 0013-936X

IS - 10

ER -