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FGF signalling modulates transcriptional repression by Xenopus groucho-related-4

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JournalBiology of the Cell
DatePublished - May 2009
Issue number5
Volume101
Number of pages8
Pages (from-to)301-308
Original languageEnglish

Abstract

Background information. Developmental cell signals co-operate in the processes of cell specification and tissue patterning during embryogenesis. Interactions between the FGF (fibroblast growth factor) and Wnt signalling pathways have been demonstrated in a number of developmental processes, including mesoderm formation in amphibian embryos. However, the mechanism underlying the interactions between these key signalling pathways remains unclear.

Results. In the present study, we find that the ability of TLE4/Xgrg4 (transducin-like enhancer of split 4/Xenopus groucho-related gene 4) to inhibit a transcriptional target of canonical Writ signalling is reduced in the presence of FGF and that this is partially dependent on a consensus site for MAPK (mitogen-activated protein kinase) phosphorylation in TLE4/Xgrg4.

Conclusions. These data suggest to us a novel molecular mechanism where FGF and Wnt signalling pathways interact at the level of the co-repressor TLE4/Xgrg4: the weakening of TLE4/Xgrg4 repression by FGF signalling, combined with the stabilization of beta-catenin by Wnt signals, enhances expression of Wnt target genes.

    Research areas

  • mesoderm, mitogen-activated protein kinase (MAPK), myogenic determination factor (MyoD), signal transduction, Wnt signalling, FIBROBLAST-GROWTH-FACTOR, MESODERM FORMATION, BETA-CATENIN, MYOD INDUCTION, MAP KINASE, EXPRESSION, WNT, EMBRYOS, GENES, EFGF

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