By the same authors

From the same journal

From the same journal

First C-H Activation Route to Oxindoles using Copper Catalysis

Research output: Contribution to journalArticle

Author(s)

Department/unit(s)

Publication details

JournalOrganic Letters
DatePublished - 6 Aug 2010
Issue number15
Volume12
Number of pages4
Pages (from-to)3446-3449
Original languageEnglish

Abstract

The preparation of 3,3-disubstituted oxindoles by a formal C-H, Ar-H coupling of anilides is described. Highly efficient conditions have been Identified using catalytic (5 mol %) Cu(OAc)(2)center dot H2O with atmospheric oxygen as the reoxidant; no additional base is required, and the reaction can be run in toluene or mesitylene. Optimization studies are reported together with a scope and limitation investigation based on variation of the anilide precursors. The application of this methodology to prepare a key Intermediate for the total synthesis of the anticancer, analgesic oxindole alkaloid Horsfiline is also described.

    Research areas

  • CARBON BOND FORMATION, INTRAMOLECULAR CYANOAMIDATION, DERIVATIVES, AGENTS

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations