By the same authors

From the same journal

From the same journal

First C-H Activation Route to Oxindoles using Copper Catalysis

Research output: Contribution to journalArticle

Standard

First C-H Activation Route to Oxindoles using Copper Catalysis. / Klein, Johannes E. M. N.; Perry, Alexis; Pugh, David S.; Taylor, Richard J. K.

In: Organic Letters, Vol. 12, No. 15, 06.08.2010, p. 3446-3449.

Research output: Contribution to journalArticle

Harvard

Klein, JEMN, Perry, A, Pugh, DS & Taylor, RJK 2010, 'First C-H Activation Route to Oxindoles using Copper Catalysis', Organic Letters, vol. 12, no. 15, pp. 3446-3449. https://doi.org/10.1021/ol1012668

APA

Klein, J. E. M. N., Perry, A., Pugh, D. S., & Taylor, R. J. K. (2010). First C-H Activation Route to Oxindoles using Copper Catalysis. Organic Letters, 12(15), 3446-3449. https://doi.org/10.1021/ol1012668

Vancouver

Klein JEMN, Perry A, Pugh DS, Taylor RJK. First C-H Activation Route to Oxindoles using Copper Catalysis. Organic Letters. 2010 Aug 6;12(15):3446-3449. https://doi.org/10.1021/ol1012668

Author

Klein, Johannes E. M. N. ; Perry, Alexis ; Pugh, David S. ; Taylor, Richard J. K. / First C-H Activation Route to Oxindoles using Copper Catalysis. In: Organic Letters. 2010 ; Vol. 12, No. 15. pp. 3446-3449.

Bibtex - Download

@article{163d94961eee4812bfc77896d06dac85,
title = "First C-H Activation Route to Oxindoles using Copper Catalysis",
abstract = "The preparation of 3,3-disubstituted oxindoles by a formal C-H, Ar-H coupling of anilides is described. Highly efficient conditions have been Identified using catalytic (5 mol %) Cu(OAc)(2)center dot H2O with atmospheric oxygen as the reoxidant; no additional base is required, and the reaction can be run in toluene or mesitylene. Optimization studies are reported together with a scope and limitation investigation based on variation of the anilide precursors. The application of this methodology to prepare a key Intermediate for the total synthesis of the anticancer, analgesic oxindole alkaloid Horsfiline is also described.",
keywords = "CARBON BOND FORMATION, INTRAMOLECULAR CYANOAMIDATION, DERIVATIVES, AGENTS",
author = "Klein, {Johannes E. M. N.} and Alexis Perry and Pugh, {David S.} and Taylor, {Richard J. K.}",
year = "2010",
month = aug,
day = "6",
doi = "10.1021/ol1012668",
language = "English",
volume = "12",
pages = "3446--3449",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "15",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - First C-H Activation Route to Oxindoles using Copper Catalysis

AU - Klein, Johannes E. M. N.

AU - Perry, Alexis

AU - Pugh, David S.

AU - Taylor, Richard J. K.

PY - 2010/8/6

Y1 - 2010/8/6

N2 - The preparation of 3,3-disubstituted oxindoles by a formal C-H, Ar-H coupling of anilides is described. Highly efficient conditions have been Identified using catalytic (5 mol %) Cu(OAc)(2)center dot H2O with atmospheric oxygen as the reoxidant; no additional base is required, and the reaction can be run in toluene or mesitylene. Optimization studies are reported together with a scope and limitation investigation based on variation of the anilide precursors. The application of this methodology to prepare a key Intermediate for the total synthesis of the anticancer, analgesic oxindole alkaloid Horsfiline is also described.

AB - The preparation of 3,3-disubstituted oxindoles by a formal C-H, Ar-H coupling of anilides is described. Highly efficient conditions have been Identified using catalytic (5 mol %) Cu(OAc)(2)center dot H2O with atmospheric oxygen as the reoxidant; no additional base is required, and the reaction can be run in toluene or mesitylene. Optimization studies are reported together with a scope and limitation investigation based on variation of the anilide precursors. The application of this methodology to prepare a key Intermediate for the total synthesis of the anticancer, analgesic oxindole alkaloid Horsfiline is also described.

KW - CARBON BOND FORMATION

KW - INTRAMOLECULAR CYANOAMIDATION

KW - DERIVATIVES

KW - AGENTS

UR - http://www.scopus.com/inward/record.url?scp=77955135659&partnerID=8YFLogxK

U2 - 10.1021/ol1012668

DO - 10.1021/ol1012668

M3 - Article

VL - 12

SP - 3446

EP - 3449

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 15

ER -