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Flow cytometric methodology for the detection of de novo human T-cell leukemia virus -1 infection in vitro: a tool to study novel infection inhibitors

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Flow cytometric methodology for the detection of de novo human T-cell leukemia virus -1 infection in vitro: a tool to study novel infection inhibitors. / Peres, Carina; Tanaka, Yuetsu; Martin, Fabiola; Fox, James Martin.

In: Journal of virological methods, Vol. 274, 113728, 08.09.2019.

Research output: Contribution to journalArticle

Harvard

Peres, C, Tanaka, Y, Martin, F & Fox, JM 2019, 'Flow cytometric methodology for the detection of de novo human T-cell leukemia virus -1 infection in vitro: a tool to study novel infection inhibitors', Journal of virological methods, vol. 274, 113728.

APA

Peres, C., Tanaka, Y., Martin, F., & Fox, J. M. (2019). Flow cytometric methodology for the detection of de novo human T-cell leukemia virus -1 infection in vitro: a tool to study novel infection inhibitors. Journal of virological methods, 274, [113728].

Vancouver

Peres C, Tanaka Y, Martin F, Fox JM. Flow cytometric methodology for the detection of de novo human T-cell leukemia virus -1 infection in vitro: a tool to study novel infection inhibitors. Journal of virological methods. 2019 Sep 8;274. 113728.

Author

Peres, Carina ; Tanaka, Yuetsu ; Martin, Fabiola ; Fox, James Martin. / Flow cytometric methodology for the detection of de novo human T-cell leukemia virus -1 infection in vitro: a tool to study novel infection inhibitors. In: Journal of virological methods. 2019 ; Vol. 274.

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@article{2090547a33f14c3b9d556ea786d62f1c,
title = "Flow cytometric methodology for the detection of de novo human T-cell leukemia virus -1 infection in vitro: a tool to study novel infection inhibitors",
abstract = "Methodology to detect and study de novo human T-cell leukemia virus (HTLV)-1 infection isrequired to further our knowledge of the viruses{\textquoteright} mechanisms of infection and to studypotential therapeutic interventions. Whilst methodology currently exists, utilisation of an anti-Tax antibody to detect de novo Tax expression in permissive cells labelled with cell trackerallowing for the detection by flow cytometry of new infection after co-culture with donor celllines productively infected with HTLV-1 is an alternative strategy. Using this methodology,we have been able to detect de novo infection of the T cell line HUT78 following co-culturewith the productively infected HTLV-1 donor cell line MT-2 and to confirm that infectioncan be effectively blocked with well characterised infection inhibitors. This methodology willbenefit experimental studies examining HTLV infection in vitro and may aid identification oftherapeutic agents that block this process.",
author = "Carina Peres and Yuetsu Tanaka and Fabiola Martin and Fox, {James Martin}",
note = "{\textcopyright} 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license. ",
year = "2019",
month = sep,
day = "8",
language = "English",
volume = "274",
journal = "Journal of virological methods",
issn = "0166-0934",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Flow cytometric methodology for the detection of de novo human T-cell leukemia virus -1 infection in vitro: a tool to study novel infection inhibitors

AU - Peres, Carina

AU - Tanaka, Yuetsu

AU - Martin, Fabiola

AU - Fox, James Martin

N1 - © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.

PY - 2019/9/8

Y1 - 2019/9/8

N2 - Methodology to detect and study de novo human T-cell leukemia virus (HTLV)-1 infection isrequired to further our knowledge of the viruses’ mechanisms of infection and to studypotential therapeutic interventions. Whilst methodology currently exists, utilisation of an anti-Tax antibody to detect de novo Tax expression in permissive cells labelled with cell trackerallowing for the detection by flow cytometry of new infection after co-culture with donor celllines productively infected with HTLV-1 is an alternative strategy. Using this methodology,we have been able to detect de novo infection of the T cell line HUT78 following co-culturewith the productively infected HTLV-1 donor cell line MT-2 and to confirm that infectioncan be effectively blocked with well characterised infection inhibitors. This methodology willbenefit experimental studies examining HTLV infection in vitro and may aid identification oftherapeutic agents that block this process.

AB - Methodology to detect and study de novo human T-cell leukemia virus (HTLV)-1 infection isrequired to further our knowledge of the viruses’ mechanisms of infection and to studypotential therapeutic interventions. Whilst methodology currently exists, utilisation of an anti-Tax antibody to detect de novo Tax expression in permissive cells labelled with cell trackerallowing for the detection by flow cytometry of new infection after co-culture with donor celllines productively infected with HTLV-1 is an alternative strategy. Using this methodology,we have been able to detect de novo infection of the T cell line HUT78 following co-culturewith the productively infected HTLV-1 donor cell line MT-2 and to confirm that infectioncan be effectively blocked with well characterised infection inhibitors. This methodology willbenefit experimental studies examining HTLV infection in vitro and may aid identification oftherapeutic agents that block this process.

M3 - Article

VL - 274

JO - Journal of virological methods

JF - Journal of virological methods

SN - 0166-0934

M1 - 113728

ER -