By the same authors

From the same journal

Fluorescence quenched quinone methide based activity probes-a cautionary tale.

Research output: Contribution to journalArticle

Author(s)

  • Robert Edwards
  • Sellars, J.D
  • Landrum, M.
  • Congreve, A.
  • Dixon, D.P
  • Moseley, J.A
  • Beeby, A.
  • Steel, P.G

Department/unit(s)

Publication details

JournalOrganic and Biomolecular Chemistry
DatePublished - 2010
Issue number7
Volume8
Number of pages9
Pages (from-to)1610-1618
Original languageEnglish

Abstract

A carbamate linked quenching group coupled with a pro-quinone methide reactive core provides an effective tool for studying enzyme function without problems associated with background fluorescence from unreacted probe. However, the relatively slow fragmentation of the carbamate linkage in such a strategy may cause problems of loss of signal or a decoupling of enzyme activity and labelling

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