The York Research Database

Water networks can determine the affinity of ligand binding to proteins

Darby, J. F., Hopkins, A., Hubbard, R. E., Roberts, S. M., Shimizu, S., Brannigan, J. A., Turkenburg, J., Thomas, G. H. & Fischer, M., 13 Sep 2019

Article in Journal of the American Chemical Society

1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

Raingeval, C., Cala, O., Brion, B., Le Borgne, M., Hubbard, R. E. & Krimm, I., 9 Jul 2019

Article in JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1

Murray, J. B., Davidson, J., Chen, I., Davis, B., Dokurno, P., Graham, C. J., Harris, R., Jordan, A., Matassova, N., Pedder, C., Ray, S., Roughley, S. D., Smith, J., Walmsley, C., Wang, Y., Whitehead, N., Williamson, D. S., Casara, P., Le Diguarher, T., Hickman, J. & 4 othersStark, J., Kotschy, A., Geneste, O. & Hubbard, R. E., 23 May 2019

Article in ACS Omega

Predicting how drug molecules bind to their protein targets

Rachman, M. M., Barril, X. & Hubbard, R. E., 1 Oct 2018

Review article in Current Opinion in Pharmacology

Using fragment-based approaches to discover new antibiotics

Hubbard, R. E. & Lamoree, B., 1 Jul 2018

Article in SLAS Discovery