Frailty predicts incident atrial fibrillation in women but not in men: The Kuopio Ischaemic Heart Disease Risk Factor Study

Behnam Tajik; Ari Voutilainen; Arja Lyytinen; Jussi Kauhanen; Gregory Y H Lip; Tomi-Pekka Tuomainen; Masoud Isanejad

doi:10.1159/000533361

Frailty predicts incident atrial fibrillation in women but not in men: The Kuopio Ischaemic Heart Disease Risk Factor Study

Behnam Tajik, Ari Voutilainen, Arja Lyytinen, Jussi Kauhanen, Gregory Y H Lip, Tomi-Pekka Tuomainen, Masoud Isanejad

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: Frailty and atrial fibrillation (AF) are common aging problems and increasing globally. The association(s) between frailty and AF have been inconclusive. The purpose of this prospective population-based cohort was to investigate the associations between frailty and incident atrial fibrillation (AF) in older men and women.

METHODS: In total 839 participants, women (n=458) and men (n=381), aged 61-74 years from the Kuopio Ischaemic Heart Disease Risk Factor Study were included (March 1, 1998, to December 31, 2001). At the baseline, among frailty prevalence was 49.3% (n=414), and non-frailty 50.7% (n=425) of the total population. Frailty was ascertained with the presence of 3-5 and prefrailty 1-2 of the following criteria: weight loss (highest 20% over 7 years), self-reported tiredness, weakness (measured by handgrip strength), slow walking speed (walking pace), and low physical activity (lowest 20%). AF events were obtained by record linkages from the national computerized hospitalization registry in Finland up to December 31, 2019. Multivariate Cox proportional hazard regression estimated the hazard ratio (HR) of incident events, adjusted for potential confounders.

RESULTS: During the mean follow-up of 14.2 years, 288 AF cases (169 women; 119 men) occurred. After adjustment for possible confounders, the HRs (95% confidence intervals (CIs)) for AF was 1.46 (1.48-1.85) in the frail population, compared to the non-frail group. The association was observed only among older frail women [multivariable-adjusted HR 1.78, 95% CI (1.28-2.48)], (P for interaction=0.04). No statistically significant associations were observed between frailty and future AF incident among men (multivariable-adjusted HRs 1.12, 95% CI (0.77-1.63).

CONCLUSIONS: In this population based epidemiological cohort, the risk of developing AF was increased in women affected by frailty at baseline but not in men.

Original language	English
Number of pages	7
Journal	Cardiology
Early online date	5 Aug 2023
DOIs	https://doi.org/10.1159/000533361
Publication status	E-pub ahead of print - 5 Aug 2023

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10.1159/000533361Licence: CC BY

000533361
© 2023 The Author(s)
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Cite this

@article{e127c13e7a574d4a8c14163ed609fcee,

title = "Frailty predicts incident atrial fibrillation in women but not in men: The Kuopio Ischaemic Heart Disease Risk Factor Study",

abstract = "INTRODUCTION: Frailty and atrial fibrillation (AF) are common aging problems and increasing globally. The association(s) between frailty and AF have been inconclusive. The purpose of this prospective population-based cohort was to investigate the associations between frailty and incident atrial fibrillation (AF) in older men and women.METHODS: In total 839 participants, women (n=458) and men (n=381), aged 61-74 years from the Kuopio Ischaemic Heart Disease Risk Factor Study were included (March 1, 1998, to December 31, 2001). At the baseline, among frailty prevalence was 49.3% (n=414), and non-frailty 50.7% (n=425) of the total population. Frailty was ascertained with the presence of 3-5 and prefrailty 1-2 of the following criteria: weight loss (highest 20% over 7 years), self-reported tiredness, weakness (measured by handgrip strength), slow walking speed (walking pace), and low physical activity (lowest 20%). AF events were obtained by record linkages from the national computerized hospitalization registry in Finland up to December 31, 2019. Multivariate Cox proportional hazard regression estimated the hazard ratio (HR) of incident events, adjusted for potential confounders.RESULTS: During the mean follow-up of 14.2 years, 288 AF cases (169 women; 119 men) occurred. After adjustment for possible confounders, the HRs (95% confidence intervals (CIs)) for AF was 1.46 (1.48-1.85) in the frail population, compared to the non-frail group. The association was observed only among older frail women [multivariable-adjusted HR 1.78, 95% CI (1.28-2.48)], (P for interaction=0.04). No statistically significant associations were observed between frailty and future AF incident among men (multivariable-adjusted HRs 1.12, 95% CI (0.77-1.63).CONCLUSIONS: In this population based epidemiological cohort, the risk of developing AF was increased in women affected by frailty at baseline but not in men.",

author = "Behnam Tajik and Ari Voutilainen and Arja Lyytinen and Jussi Kauhanen and Lip, {Gregory Y H} and Tomi-Pekka Tuomainen and Masoud Isanejad",

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year = "2023",

month = aug,

day = "5",

doi = "10.1159/000533361",

language = "English",

journal = "Cardiology",

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TY - JOUR

T1 - Frailty predicts incident atrial fibrillation in women but not in men

T2 - The Kuopio Ischaemic Heart Disease Risk Factor Study

AU - Tajik, Behnam

AU - Voutilainen, Ari

AU - Lyytinen, Arja

AU - Kauhanen, Jussi

AU - Lip, Gregory Y H

AU - Tuomainen, Tomi-Pekka

AU - Isanejad, Masoud

PY - 2023/8/5

Y1 - 2023/8/5

N2 - INTRODUCTION: Frailty and atrial fibrillation (AF) are common aging problems and increasing globally. The association(s) between frailty and AF have been inconclusive. The purpose of this prospective population-based cohort was to investigate the associations between frailty and incident atrial fibrillation (AF) in older men and women.METHODS: In total 839 participants, women (n=458) and men (n=381), aged 61-74 years from the Kuopio Ischaemic Heart Disease Risk Factor Study were included (March 1, 1998, to December 31, 2001). At the baseline, among frailty prevalence was 49.3% (n=414), and non-frailty 50.7% (n=425) of the total population. Frailty was ascertained with the presence of 3-5 and prefrailty 1-2 of the following criteria: weight loss (highest 20% over 7 years), self-reported tiredness, weakness (measured by handgrip strength), slow walking speed (walking pace), and low physical activity (lowest 20%). AF events were obtained by record linkages from the national computerized hospitalization registry in Finland up to December 31, 2019. Multivariate Cox proportional hazard regression estimated the hazard ratio (HR) of incident events, adjusted for potential confounders.RESULTS: During the mean follow-up of 14.2 years, 288 AF cases (169 women; 119 men) occurred. After adjustment for possible confounders, the HRs (95% confidence intervals (CIs)) for AF was 1.46 (1.48-1.85) in the frail population, compared to the non-frail group. The association was observed only among older frail women [multivariable-adjusted HR 1.78, 95% CI (1.28-2.48)], (P for interaction=0.04). No statistically significant associations were observed between frailty and future AF incident among men (multivariable-adjusted HRs 1.12, 95% CI (0.77-1.63).CONCLUSIONS: In this population based epidemiological cohort, the risk of developing AF was increased in women affected by frailty at baseline but not in men.

AB - INTRODUCTION: Frailty and atrial fibrillation (AF) are common aging problems and increasing globally. The association(s) between frailty and AF have been inconclusive. The purpose of this prospective population-based cohort was to investigate the associations between frailty and incident atrial fibrillation (AF) in older men and women.METHODS: In total 839 participants, women (n=458) and men (n=381), aged 61-74 years from the Kuopio Ischaemic Heart Disease Risk Factor Study were included (March 1, 1998, to December 31, 2001). At the baseline, among frailty prevalence was 49.3% (n=414), and non-frailty 50.7% (n=425) of the total population. Frailty was ascertained with the presence of 3-5 and prefrailty 1-2 of the following criteria: weight loss (highest 20% over 7 years), self-reported tiredness, weakness (measured by handgrip strength), slow walking speed (walking pace), and low physical activity (lowest 20%). AF events were obtained by record linkages from the national computerized hospitalization registry in Finland up to December 31, 2019. Multivariate Cox proportional hazard regression estimated the hazard ratio (HR) of incident events, adjusted for potential confounders.RESULTS: During the mean follow-up of 14.2 years, 288 AF cases (169 women; 119 men) occurred. After adjustment for possible confounders, the HRs (95% confidence intervals (CIs)) for AF was 1.46 (1.48-1.85) in the frail population, compared to the non-frail group. The association was observed only among older frail women [multivariable-adjusted HR 1.78, 95% CI (1.28-2.48)], (P for interaction=0.04). No statistically significant associations were observed between frailty and future AF incident among men (multivariable-adjusted HRs 1.12, 95% CI (0.77-1.63).CONCLUSIONS: In this population based epidemiological cohort, the risk of developing AF was increased in women affected by frailty at baseline but not in men.

U2 - 10.1159/000533361

DO - 10.1159/000533361

M3 - Article

C2 - 37544295

SN - 0008-6312

JO - Cardiology

JF - Cardiology

ER -