From Natural Methylation to Versatile Alkylations Using Halide Methyltransferases

Qingyun Tang

doi:10.1002/cbic.202100153

From Natural Methylation to Versatile Alkylations Using Halide Methyltransferases

Qingyun Tang

Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

Naturally occurring and engineered promiscuous halide methyltransferases (HMTs) enable S-adenosyl-l-methionine analogues to be enzymatically synthesised and recycled, using simple and readily available alkyl iodides as alkyl donors. In combination with promiscuous methyltransferases (MTs), they dramatically expand the bioalkylation toolbox.

Original language	English
Pages (from-to)	2584-2590
Number of pages	7
Journal	Chembiochem
Volume	22
Issue number	16
Early online date	10 May 2021
DOIs	https://doi.org/10.1002/cbic.202100153
Publication status	Published - 17 Aug 2021

Bibliographical note

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10.1002/cbic.202100153Licence: CC BY

From Natural Methylation to Versatile Alkylations Using Halide Methyltransferases
© 2021 The Authors.
Final published version, 5.41 MBLicence: CC BY

Cite this

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abstract = "Naturally occurring and engineered promiscuous halide methyltransferases (HMTs) enable S-adenosyl-l-methionine analogues to be enzymatically synthesised and recycled, using simple and readily available alkyl iodides as alkyl donors. In combination with promiscuous methyltransferases (MTs), they dramatically expand the bioalkylation toolbox.",

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AB - Naturally occurring and engineered promiscuous halide methyltransferases (HMTs) enable S-adenosyl-l-methionine analogues to be enzymatically synthesised and recycled, using simple and readily available alkyl iodides as alkyl donors. In combination with promiscuous methyltransferases (MTs), they dramatically expand the bioalkylation toolbox.

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DO - 10.1002/cbic.202100153

M3 - Review article

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