By the same authors

From the same journal

Gankyrin: a new oncoprotein and regulator of pRb and p53

Research output: Contribution to journalLiterature review

Published copy (DOI)

Author(s)

Department/unit(s)

Publication details

JournalTRENDS IN CELL BIOLOGY
DatePublished - May 2006
Issue number5
Volume16
Number of pages5
Pages (from-to)229-233
Original languageEnglish

Abstract

Gankyrin is a new oncoprotein with potent cell cycle and apoptotic properties that is overexpressed early in hepatocarcinogenesis and in hepatocellular carcinomas. Gankyrin regulates the phosphorylation of the retinoblastoma protein (pRb) by CDK4 and enhances the ubiquitylation of p53 by the RING ubiquitin ligase MDM2. Purified preparations of the 26S proteasome contain gankyrin, which specifically interacts with the S6b (Rpt3) ATPase of the 19S regulator. In conclusion, gankyrin is a small versatile cell cycle regulator that illustrates the essential interplay between the ubiquitin proteasome system and gene expression in the cell. Here, we discuss the activities of gankyrin and present a model for its function in the regulation of pRb and p53.

    Research areas

  • UBIQUITIN-PROTEASOME SYSTEM, HEPATOCELLULAR-CARCINOMA, CRYSTAL-STRUCTURE, 26S PROTEASOME, RETINOBLASTOMA PROTEIN, FUNCTIONAL-ANALYSIS, DNA-REPAIR, STABILITY, DEGRADATION, YEAST

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations