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Gankyrin: a new oncoprotein and regulator of pRb and p53

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Gankyrin: a new oncoprotein and regulator of pRb and p53. / Dawson, S ; Higashitsuji, H ; Wilkinson, A J ; Fujita, J ; Mayer, R J .

In: TRENDS IN CELL BIOLOGY, Vol. 16, No. 5, 05.2006, p. 229-233.

Research output: Contribution to journalLiterature reviewpeer-review

Harvard

Dawson, S, Higashitsuji, H, Wilkinson, AJ, Fujita, J & Mayer, RJ 2006, 'Gankyrin: a new oncoprotein and regulator of pRb and p53', TRENDS IN CELL BIOLOGY, vol. 16, no. 5, pp. 229-233. https://doi.org/10.1016/j.tcb.2006.03.001

APA

Dawson, S., Higashitsuji, H., Wilkinson, A. J., Fujita, J., & Mayer, R. J. (2006). Gankyrin: a new oncoprotein and regulator of pRb and p53. TRENDS IN CELL BIOLOGY, 16(5), 229-233. https://doi.org/10.1016/j.tcb.2006.03.001

Vancouver

Dawson S, Higashitsuji H, Wilkinson AJ, Fujita J, Mayer RJ. Gankyrin: a new oncoprotein and regulator of pRb and p53. TRENDS IN CELL BIOLOGY. 2006 May;16(5):229-233. https://doi.org/10.1016/j.tcb.2006.03.001

Author

Dawson, S ; Higashitsuji, H ; Wilkinson, A J ; Fujita, J ; Mayer, R J . / Gankyrin: a new oncoprotein and regulator of pRb and p53. In: TRENDS IN CELL BIOLOGY. 2006 ; Vol. 16, No. 5. pp. 229-233.

Bibtex - Download

@article{c1e016fe36e748f99dbdad6458d6a769,
title = "Gankyrin: a new oncoprotein and regulator of pRb and p53",
abstract = "Gankyrin is a new oncoprotein with potent cell cycle and apoptotic properties that is overexpressed early in hepatocarcinogenesis and in hepatocellular carcinomas. Gankyrin regulates the phosphorylation of the retinoblastoma protein (pRb) by CDK4 and enhances the ubiquitylation of p53 by the RING ubiquitin ligase MDM2. Purified preparations of the 26S proteasome contain gankyrin, which specifically interacts with the S6b (Rpt3) ATPase of the 19S regulator. In conclusion, gankyrin is a small versatile cell cycle regulator that illustrates the essential interplay between the ubiquitin proteasome system and gene expression in the cell. Here, we discuss the activities of gankyrin and present a model for its function in the regulation of pRb and p53.",
keywords = "UBIQUITIN-PROTEASOME SYSTEM, HEPATOCELLULAR-CARCINOMA, CRYSTAL-STRUCTURE, 26S PROTEASOME, RETINOBLASTOMA PROTEIN, FUNCTIONAL-ANALYSIS, DNA-REPAIR, STABILITY, DEGRADATION, YEAST",
author = "S Dawson and H Higashitsuji and Wilkinson, {A J} and J Fujita and Mayer, {R J}",
year = "2006",
month = may,
doi = "10.1016/j.tcb.2006.03.001",
language = "English",
volume = "16",
pages = "229--233",
journal = "TRENDS IN CELL BIOLOGY",
issn = "0962-8924",
publisher = "Elsevier Limited",
number = "5",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Gankyrin: a new oncoprotein and regulator of pRb and p53

AU - Dawson, S

AU - Higashitsuji, H

AU - Wilkinson, A J

AU - Fujita, J

AU - Mayer, R J

PY - 2006/5

Y1 - 2006/5

N2 - Gankyrin is a new oncoprotein with potent cell cycle and apoptotic properties that is overexpressed early in hepatocarcinogenesis and in hepatocellular carcinomas. Gankyrin regulates the phosphorylation of the retinoblastoma protein (pRb) by CDK4 and enhances the ubiquitylation of p53 by the RING ubiquitin ligase MDM2. Purified preparations of the 26S proteasome contain gankyrin, which specifically interacts with the S6b (Rpt3) ATPase of the 19S regulator. In conclusion, gankyrin is a small versatile cell cycle regulator that illustrates the essential interplay between the ubiquitin proteasome system and gene expression in the cell. Here, we discuss the activities of gankyrin and present a model for its function in the regulation of pRb and p53.

AB - Gankyrin is a new oncoprotein with potent cell cycle and apoptotic properties that is overexpressed early in hepatocarcinogenesis and in hepatocellular carcinomas. Gankyrin regulates the phosphorylation of the retinoblastoma protein (pRb) by CDK4 and enhances the ubiquitylation of p53 by the RING ubiquitin ligase MDM2. Purified preparations of the 26S proteasome contain gankyrin, which specifically interacts with the S6b (Rpt3) ATPase of the 19S regulator. In conclusion, gankyrin is a small versatile cell cycle regulator that illustrates the essential interplay between the ubiquitin proteasome system and gene expression in the cell. Here, we discuss the activities of gankyrin and present a model for its function in the regulation of pRb and p53.

KW - UBIQUITIN-PROTEASOME SYSTEM

KW - HEPATOCELLULAR-CARCINOMA

KW - CRYSTAL-STRUCTURE

KW - 26S PROTEASOME

KW - RETINOBLASTOMA PROTEIN

KW - FUNCTIONAL-ANALYSIS

KW - DNA-REPAIR

KW - STABILITY

KW - DEGRADATION

KW - YEAST

U2 - 10.1016/j.tcb.2006.03.001

DO - 10.1016/j.tcb.2006.03.001

M3 - Literature review

VL - 16

SP - 229

EP - 233

JO - TRENDS IN CELL BIOLOGY

JF - TRENDS IN CELL BIOLOGY

SN - 0962-8924

IS - 5

ER -