By the same authors

From the same journal

Gene Transfer Vectors Targeted to Human Prostate Cancer: Do We Need Better Preclinical Testing Systems?

Research output: Contribution to journalArticle

Published copy (DOI)

Author(s)

  • Norman Maitland
  • Karen Chambers
  • Lindsay Georgopoulos
  • Martha Simpson-Holley
  • Regina Leadley
  • Helen Evans
  • Magnus Essand
  • Angelika Danielsson
  • Wytske van Weerden
  • Corrina de Ridder
  • Robert Kraaij
  • Chris H. Bangma
  • GIANT FP6 Consortium

Department/unit(s)

Publication details

JournalHUMAN GENE THERAPY
DatePublished - Jul 2010
Issue number7
Volume21
Number of pages13
Pages (from-to)815-827
Original languageEnglish

Abstract

Destruction of cancer cells by genetically modified viral and nonviral vectors has been the aim of many research programs. The ability to target cytotoxic gene therapies to the cells of interest is an essential prerequisite, and the treatment has always had the potential to provide better and more long-lasting therapy than existing chemotherapies. However, the potency of these infectious agents requires effective testing systems, in which hypotheses can be explored both in vitro and in vivo before the establishment of clinical trials in humans. The real prospect of off-target effects should be eliminated in the preclinical stage, if current prejudices against such therapies are to be overcome. In this review we have set out, using adenoviral vectors as a commonly used example, to discuss some of the key parameters required to develop more effective testing, and to critically assess the current cellular models for the development and testing of prostate cancer biotherapy. Only by developing models that more closely mirror human tissues will we be able to translate literature publications into clinical trials and hence into acceptable alternative treatments for the most commonly diagnosed cancer in humans.

    Research areas

  • CARCINOMA-CELL-LINE, INNATE IMMUNE-RESPONSES, ADENOVIRUS RECEPTOR, STEM-CELLS, EPITHELIAL-CELLS, ANDROGEN RECEPTOR, TIGHT JUNCTIONS, STROMAL CELLS, TUMOR-CELLS, IN-VITRO

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