TY - JOUR
T1 - Genetic pest management and the background genetics of release strains
T2 - GPM & background genetics
AU - Leftwich, Philip T.
AU - Spurgin, Lewis G.
AU - Harvey-Samuel, Tim
AU - Thomas, Callum J.E.
AU - Paladino, Leonela Carabajal
AU - Edgington, Matthew P.
AU - Alphey, Luke
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2021/2/15
Y1 - 2021/2/15
N2 - Genetic pest management (GPM) methods involve releasing modified versions of a pest species to mate with wild pests in the target area. Proposed for a wide range of applications in public health, agriculture and conservation, most progress has been made with pest insects. Offspring of the released modified insects and wild pests carry the modification-which might be transgenes, artificially introduced Wolbachia or genetic damage from radiation, for example-but they also carry a complete haploid genome from their laboratory-reared parent, as well as one from their wild parent. Unless these F 1 hybrids are completely unable to reproduce, further mating will lead to introgression of DNA sequences from the release strain into the wild population. We discuss issues around strain selection and the potential consequences of such introgression. We conclude that such introgression is probably harmless in almost all circumstances, and could, in theory, provide specific additional benefits to the release programme. We outline population monitoring approaches that could be used, going forward, to determine how background genetics may affect GPM. This article is part of the theme issue 'Novel control strategies for mosquito-borne diseases'.
AB - Genetic pest management (GPM) methods involve releasing modified versions of a pest species to mate with wild pests in the target area. Proposed for a wide range of applications in public health, agriculture and conservation, most progress has been made with pest insects. Offspring of the released modified insects and wild pests carry the modification-which might be transgenes, artificially introduced Wolbachia or genetic damage from radiation, for example-but they also carry a complete haploid genome from their laboratory-reared parent, as well as one from their wild parent. Unless these F 1 hybrids are completely unable to reproduce, further mating will lead to introgression of DNA sequences from the release strain into the wild population. We discuss issues around strain selection and the potential consequences of such introgression. We conclude that such introgression is probably harmless in almost all circumstances, and could, in theory, provide specific additional benefits to the release programme. We outline population monitoring approaches that could be used, going forward, to determine how background genetics may affect GPM. This article is part of the theme issue 'Novel control strategies for mosquito-borne diseases'.
KW - Aedes aegypti
KW - gene flow
KW - introgression
KW - population genetics
KW - release of insects carrying a dominant lethal
KW - sterile-insect technique
UR - http://www.scopus.com/inward/record.url?scp=85099076024&partnerID=8YFLogxK
U2 - 10.1098/rstb.2019.0805
DO - 10.1098/rstb.2019.0805
M3 - Review article
C2 - 33357053
AN - SCOPUS:85099076024
SN - 0962-8436
VL - 376
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
IS - 1818
M1 - 20190804
ER -