Genetically Determined Height and Risk of Non-hodgkin Lymphoma

Amy Moore; Eleanor Victoria Kane; Zhaoming Wang; Orestis Panagiotou; Lauren R Teras; Alain Monnereau; Nicole Wong Doo; Mitchell John  Machiela; Christine F. Skibola; Susan L. Slager; Gilles Salles; Nicola J Camp; Paige M. Bracci; Alexandra Nieters; Roel C H Vermeulen; Joseph Vijai; Karin E. Smedby; Yawei Zhang; Claire M. Vajdic; Wendy Cozen; John J. Spinelli; Henrik Hjalgrim; Graham G. Giles; Brian K Link; Jacqueline Clavel; Alan A Arslan; Mark P Purdue; Lesley F Tinker; Demetrius Albanes; Giovanni M Ferri; Thomas M Habermann; Hans-Olov Adami; Nikolaus Becker; Yolanda Benavente; Simonetta  Bisanzi; Paolo Boffetta; Paul Brennan; Angela R Brooks-Wilson; Federico Canzian; Lucia Conde; David G Cox; Karen Curtin; Lenka Foretova; Susan M Gapstur; Hervé Ghesquières; Martha Glenn; Bengt Glimelius; Rebecca D Jackson; Qing Lan; Mark Liebow; Marc Maynadie; James D McKay; Mads Melbye; Lucia Miligi; Roger L Milne; Thierry Jo Molina; Lindsay M. Morton; Kari E North; Kenneth Offit; Marina  Padoan; Alpa V  Patel; Sara  Piro; Vignesh  Ravichandran; Elio Riboli; Silvia de Sanjose; Richard K. Severson; Melissa Caroline  Southey; Anthony Staines; Carolyn Stewart; Ruth C. Travis; Elisabete Weiderpass; Stephanie Weinstein; Tongzhang Zheng; Stephen J. Chanock; Nilanjan Chatterjee; Nathaniel Rothman; Brenda M Birmann; James R. Cerhan; Sonja I Berndt

doi:10.3389/fonc.2019.01539

Genetically Determined Height and Risk of Non-hodgkin Lymphoma

Amy Moore, Eleanor Victoria Kane, Zhaoming Wang, Orestis Panagiotou, Lauren R Teras, Alain Monnereau, Nicole Wong Doo, Mitchell John Machiela, Christine F. Skibola, Susan L. Slager, Gilles Salles, Nicola J Camp, Paige M. Bracci, Alexandra Nieters, Roel C H Vermeulen, Joseph Vijai, Karin E. Smedby, Yawei Zhang, Claire M. Vajdic, Wendy CozenJohn J. Spinelli, Henrik Hjalgrim, Graham G. Giles, Brian K Link, Jacqueline Clavel, Alan A Arslan, Mark P Purdue, Lesley F Tinker, Demetrius Albanes, Giovanni M Ferri, Thomas M Habermann, Hans-Olov Adami, Nikolaus Becker, Yolanda Benavente, Simonetta Bisanzi, Paolo Boffetta, Paul Brennan, Angela R Brooks-Wilson, Federico Canzian, Lucia Conde, David G Cox, Karen Curtin, Lenka Foretova, Susan M Gapstur, Hervé Ghesquières, Martha Glenn, Bengt Glimelius, Rebecca D Jackson, Qing Lan, Mark Liebow, Marc Maynadie, James D McKay, Mads Melbye, Lucia Miligi, Roger L Milne, Thierry Jo Molina, Lindsay M. Morton, Kari E North, Kenneth Offit, Marina Padoan, Alpa V Patel, Sara Piro, Vignesh Ravichandran, Elio Riboli, Silvia de Sanjose, Richard K. Severson, Melissa Caroline Southey, Anthony Staines, Carolyn Stewart, Ruth C. Travis, Elisabete Weiderpass, Stephanie Weinstein, Tongzhang Zheng, Stephen J. Chanock, Nilanjan Chatterjee, Nathaniel Rothman, Brenda M Birmann, James R. Cerhan, Sonja I Berndt

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.

Original language	English
Article number	1539
Number of pages	8
Journal	Frontiers in Oncology
Volume	9
DOIs	https://doi.org/10.3389/fonc.2019.01539
Publication status	Published - 28 Jan 2020

Bibliographical note

© 2020 Moore, Kane, Wang, Panagiotou, Teras, Monnereau, Wong Doo, Machiela, Skibola, Slager, Salles, Camp, Bracci, Nieters, Vermeulen, Vijai, Smedby, Zhang, Vajdic, Cozen, Spinelli, Hjalgrim, Giles, Link, Clavel, Arslan, Purdue, Tinker, Albanes, Ferri, Habermann, Adami, Becker, Benavente, Bisanzi, Boffetta, Brennan, Brooks-Wilson, Canzian, Conde, Cox, Curtin, Foretova, Gapstur, Ghesquières, Glenn, Glimelius, Jackson, Lan, Liebow, Maynadie, McKay, Melbye, Miligi, Milne, Molina, Morton, North, Offit, Padoan, Patel, Piro, Ravichandran, Riboli, de Sanjose, Severson, Southey, Staines, Stewart, Travis, Weiderpass, Weinstein, Zheng, Chanock, Chatterjee, Rothman, Birmann, Cerhan and Berndt. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

Access to Document

10.3389/fonc.2019.01539

FONC_InterLymph_NHL_HeightGenetics
© 2020 Moore, Kane, Wang, Panagiotou, Teras, Monnereau, Wong Doo, Machiela, Skibola, Slager, Salles, Camp, Bracci, Nieters, Vermeulen, Vijai, Smedby, Zhang, Vajdic, Cozen, Spinelli, Hjalgrim, Giles, Link, Clavel, Arslan, Purdue, Tinker, Albanes, Ferri, Habermann, Adami, Becker, Benavente, Bisanzi, Boffetta, Brennan, Brooks-Wilson, Canzian, Conde, Cox, Curtin, Foretova, Gapstur, Ghesquières, Glenn, Glimelius, Jackson, Lan, Liebow, Maynadie, McKay, Melbye, Miligi, Milne, Molina, Morton, North, Offit, Padoan, Patel, Piro, Ravichandran, Riboli, de Sanjose, Severson, Southey, Staines, Stewart, Travis, Weiderpass, Weinstein, Zheng, Chanock, Chatterjee, Rothman, Birmann, Cerhan and Berndt. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details
Final published version, 369 KBLicence: CC BY

https://www.frontiersin.org/articles/10.3389/fonc.2019.01539/full

Cite this

Moore, A., Kane, E. V., Wang, Z., Panagiotou, O., Teras, L. R., Monnereau, A., Wong Doo, N., Machiela, M. J., Skibola, C. F., Slager, S. L., Salles, G., Camp, N. J., Bracci, P. M., Nieters, A., Vermeulen, R. C. H., Vijai, J., Smedby, K. E., Zhang, Y., Vajdic, C. M., ... Berndt, S. I. (2020). Genetically Determined Height and Risk of Non-hodgkin Lymphoma. Frontiers in Oncology, 9, Article 1539. https://doi.org/10.3389/fonc.2019.01539

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title = "Genetically Determined Height and Risk of Non-hodgkin Lymphoma",

abstract = "Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.",

author = "Amy Moore and Kane, {Eleanor Victoria} and Zhaoming Wang and Orestis Panagiotou and Teras, {Lauren R} and Alain Monnereau and {Wong Doo}, Nicole and Machiela, {Mitchell John} and Skibola, {Christine F.} and Slager, {Susan L.} and Gilles Salles and Camp, {Nicola J} and Bracci, {Paige M.} and Alexandra Nieters and Vermeulen, {Roel C H} and Joseph Vijai and Smedby, {Karin E.} and Yawei Zhang and Vajdic, {Claire M.} and Wendy Cozen and Spinelli, {John J.} and Henrik Hjalgrim and Giles, {Graham G.} and Link, {Brian K} and Jacqueline Clavel and Arslan, {Alan A} and Purdue, {Mark P} and Tinker, {Lesley F} and Demetrius Albanes and Ferri, {Giovanni M} and Habermann, {Thomas M} and Hans-Olov Adami and Nikolaus Becker and Yolanda Benavente and Simonetta Bisanzi and Paolo Boffetta and Paul Brennan and Brooks-Wilson, {Angela R} and Federico Canzian and Lucia Conde and Cox, {David G} and Karen Curtin and Lenka Foretova and Gapstur, {Susan M} and Herv{\'e} Ghesqui{\`e}res and Martha Glenn and Bengt Glimelius and Jackson, {Rebecca D} and Qing Lan and Mark Liebow and Marc Maynadie and McKay, {James D} and Mads Melbye and Lucia Miligi and Milne, {Roger L} and Molina, {Thierry Jo} and Morton, {Lindsay M.} and North, {Kari E} and Kenneth Offit and Marina Padoan and Patel, {Alpa V} and Sara Piro and Vignesh Ravichandran and Elio Riboli and {de Sanjose}, Silvia and Severson, {Richard K.} and Southey, {Melissa Caroline} and Anthony Staines and Carolyn Stewart and Travis, {Ruth C.} and Elisabete Weiderpass and Stephanie Weinstein and Tongzhang Zheng and Chanock, {Stephen J.} and Nilanjan Chatterjee and Nathaniel Rothman and Birmann, {Brenda M} and Cerhan, {James R.} and Berndt, {Sonja I}",

note = "{\textcopyright} 2020 Moore, Kane, Wang, Panagiotou, Teras, Monnereau, Wong Doo, Machiela, Skibola, Slager, Salles, Camp, Bracci, Nieters, Vermeulen, Vijai, Smedby, Zhang, Vajdic, Cozen, Spinelli, Hjalgrim, Giles, Link, Clavel, Arslan, Purdue, Tinker, Albanes, Ferri, Habermann, Adami, Becker, Benavente, Bisanzi, Boffetta, Brennan, Brooks-Wilson, Canzian, Conde, Cox, Curtin, Foretova, Gapstur, Ghesqui{\`e}res, Glenn, Glimelius, Jackson, Lan, Liebow, Maynadie, McKay, Melbye, Miligi, Milne, Molina, Morton, North, Offit, Padoan, Patel, Piro, Ravichandran, Riboli, de Sanjose, Severson, Southey, Staines, Stewart, Travis, Weiderpass, Weinstein, Zheng, Chanock, Chatterjee, Rothman, Birmann, Cerhan and Berndt. Uploaded in accordance with the publisher{\textquoteright}s self-archiving policy. Further copying may not be permitted; contact the publisher for details ",

year = "2020",

month = jan,

day = "28",

doi = "10.3389/fonc.2019.01539",

language = "English",

volume = "9",

journal = "Frontiers in Oncology",

issn = "2234-943X",

publisher = "Frontiers Media S.A.",

}

Moore, A, Kane, EV, Wang, Z, Panagiotou, O, Teras, LR, Monnereau, A, Wong Doo, N, Machiela, MJ, Skibola, CF, Slager, SL, Salles, G, Camp, NJ, Bracci, PM, Nieters, A, Vermeulen, RCH, Vijai, J, Smedby, KE, Zhang, Y, Vajdic, CM, Cozen, W, Spinelli, JJ, Hjalgrim, H, Giles, GG, Link, BK, Clavel, J, Arslan, AA, Purdue, MP, Tinker, LF, Albanes, D, Ferri, GM, Habermann, TM, Adami, H-O, Becker, N, Benavente, Y, Bisanzi, S, Boffetta, P, Brennan, P, Brooks-Wilson, AR, Canzian, F, Conde, L, Cox, DG, Curtin, K, Foretova, L, Gapstur, SM, Ghesquières, H, Glenn, M, Glimelius, B, Jackson, RD, Lan, Q, Liebow, M, Maynadie, M, McKay, JD, Melbye, M, Miligi, L, Milne, RL, Molina, TJ, Morton, LM, North, KE, Offit, K, Padoan, M, Patel, AV, Piro, S, Ravichandran, V, Riboli, E, de Sanjose, S, Severson, RK, Southey, MC, Staines, A, Stewart, C, Travis, RC, Weiderpass, E, Weinstein, S, Zheng, T, Chanock, SJ, Chatterjee, N, Rothman, N, Birmann, BM, Cerhan, JR & Berndt, SI 2020, 'Genetically Determined Height and Risk of Non-hodgkin Lymphoma', Frontiers in Oncology, vol. 9, 1539. https://doi.org/10.3389/fonc.2019.01539

TY - JOUR

T1 - Genetically Determined Height and Risk of Non-hodgkin Lymphoma

AU - Moore, Amy

AU - Kane, Eleanor Victoria

AU - Wang, Zhaoming

AU - Panagiotou, Orestis

AU - Teras, Lauren R

AU - Monnereau, Alain

AU - Wong Doo, Nicole

AU - Machiela, Mitchell John

AU - Skibola, Christine F.

AU - Slager, Susan L.

AU - Salles, Gilles

AU - Camp, Nicola J

AU - Bracci, Paige M.

AU - Nieters, Alexandra

AU - Vermeulen, Roel C H

AU - Vijai, Joseph

AU - Smedby, Karin E.

AU - Zhang, Yawei

AU - Vajdic, Claire M.

AU - Cozen, Wendy

AU - Spinelli, John J.

AU - Hjalgrim, Henrik

AU - Giles, Graham G.

AU - Link, Brian K

AU - Clavel, Jacqueline

AU - Arslan, Alan A

AU - Purdue, Mark P

AU - Tinker, Lesley F

AU - Albanes, Demetrius

AU - Ferri, Giovanni M

AU - Habermann, Thomas M

AU - Adami, Hans-Olov

AU - Becker, Nikolaus

AU - Benavente, Yolanda

AU - Bisanzi, Simonetta

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Brooks-Wilson, Angela R

AU - Canzian, Federico

AU - Conde, Lucia

AU - Cox, David G

AU - Curtin, Karen

AU - Foretova, Lenka

AU - Gapstur, Susan M

AU - Ghesquières, Hervé

AU - Glenn, Martha

AU - Glimelius, Bengt

AU - Jackson, Rebecca D

AU - Lan, Qing

AU - Liebow, Mark

AU - Maynadie, Marc

AU - McKay, James D

AU - Melbye, Mads

AU - Miligi, Lucia

AU - Milne, Roger L

AU - Molina, Thierry Jo

AU - Morton, Lindsay M.

AU - North, Kari E

AU - Offit, Kenneth

AU - Padoan, Marina

AU - Patel, Alpa V

AU - Piro, Sara

AU - Ravichandran, Vignesh

AU - Riboli, Elio

AU - de Sanjose, Silvia

AU - Severson, Richard K.

AU - Southey, Melissa Caroline

AU - Staines, Anthony

AU - Stewart, Carolyn

AU - Travis, Ruth C.

AU - Weiderpass, Elisabete

AU - Weinstein, Stephanie

AU - Zheng, Tongzhang

AU - Chanock, Stephen J.

AU - Chatterjee, Nilanjan

AU - Rothman, Nathaniel

AU - Birmann, Brenda M

AU - Cerhan, James R.

AU - Berndt, Sonja I

N1 - © 2020 Moore, Kane, Wang, Panagiotou, Teras, Monnereau, Wong Doo, Machiela, Skibola, Slager, Salles, Camp, Bracci, Nieters, Vermeulen, Vijai, Smedby, Zhang, Vajdic, Cozen, Spinelli, Hjalgrim, Giles, Link, Clavel, Arslan, Purdue, Tinker, Albanes, Ferri, Habermann, Adami, Becker, Benavente, Bisanzi, Boffetta, Brennan, Brooks-Wilson, Canzian, Conde, Cox, Curtin, Foretova, Gapstur, Ghesquières, Glenn, Glimelius, Jackson, Lan, Liebow, Maynadie, McKay, Melbye, Miligi, Milne, Molina, Morton, North, Offit, Padoan, Patel, Piro, Ravichandran, Riboli, de Sanjose, Severson, Southey, Staines, Stewart, Travis, Weiderpass, Weinstein, Zheng, Chanock, Chatterjee, Rothman, Birmann, Cerhan and Berndt. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

PY - 2020/1/28

Y1 - 2020/1/28

N2 - Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.

AB - Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.

U2 - 10.3389/fonc.2019.01539

DO - 10.3389/fonc.2019.01539

M3 - Article

SN - 2234-943X

VL - 9

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 1539

ER -