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Genetically Determined Height and Risk of Non-hodgkin Lymphoma

Research output: Contribution to journalArticle

Author(s)

  • Amy Moore
  • Zhaoming Wang
  • Orestis Panagiotou
  • Lauren R Teras
  • Alain Monnereau
  • Nicole Wong Doo
  • Mitchell John Machiela
  • Christine F. Skibola
  • Susan L. Slager
  • Gilles Salles
  • Nicola J Camp
  • Paige M. Bracci
  • Alexandra Nieters
  • Roel C H Vermeulen
  • Joseph Vijai
  • Karin E. Smedby
  • Yawei Zhang
  • Claire M. Vajdic
  • Wendy Cozen
  • John J. Spinelli
  • Henrik Hjalgrim
  • Graham G. Giles
  • Brian K Link
  • Jacqueline Clavel
  • Alan A Arslan
  • Mark P Purdue
  • Lesley F Tinker
  • Demetrius Albanes
  • Giovanni M Ferri
  • Thomas M Habermann
  • Hans-Olov Adami
  • Nikolaus Becker
  • Yolanda Benavente
  • Simonetta Bisanzi
  • Paolo Boffetta
  • Paul Brennan
  • Angela R Brooks-Wilson
  • Federico Canzian
  • Lucia Conde
  • David G Cox
  • Karen Curtin
  • Lenka Foretova
  • Susan M Gapstur
  • Hervé Ghesquières
  • Martha Glenn
  • Bengt Glimelius
  • Rebecca D Jackson
  • Qing Lan
  • Mark Liebow
  • Marc Maynadie
  • James D McKay
  • Mads Melbye
  • Lucia Miligi
  • Roger L Milne
  • Thierry Jo Molina
  • Lindsay M. Morton
  • Kari E North
  • Kenneth Offit
  • Marina Padoan
  • Alpa V Patel
  • Sara Piro
  • Vignesh Ravichandran
  • Elio Riboli
  • Silvia de Sanjose
  • Richard K. Severson
  • Melissa Caroline Southey
  • Anthony Staines
  • Carolyn Stewart
  • Ruth C. Travis
  • Elisabete Weiderpass
  • Stephanie Weinstein
  • Tongzhang Zheng
  • Stephen J. Chanock
  • Nilanjan Chatterjee
  • Nathaniel Rothman
  • Brenda M Birmann
  • James R. Cerhan
  • Sonja I Berndt

Department/unit(s)

Publication details

JournalFrontiers in Oncology
DateAccepted/In press - 19 Dec 2019
DatePublished (current) - 28 Jan 2020
Volume9
Number of pages8
Original languageEnglish

Abstract

Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.

Bibliographical note

© 2020 Moore, Kane, Wang, Panagiotou, Teras, Monnereau, Wong Doo, Machiela, Skibola, Slager, Salles, Camp, Bracci, Nieters, Vermeulen, Vijai, Smedby, Zhang, Vajdic, Cozen, Spinelli, Hjalgrim, Giles, Link, Clavel, Arslan, Purdue, Tinker, Albanes, Ferri, Habermann, Adami, Becker, Benavente, Bisanzi, Boffetta, Brennan, Brooks-Wilson, Canzian, Conde, Cox, Curtin, Foretova, Gapstur, Ghesquières, Glenn, Glimelius, Jackson, Lan, Liebow, Maynadie, McKay, Melbye, Miligi, Milne, Molina, Morton, North, Offit, Padoan, Patel, Piro, Ravichandran, Riboli, de Sanjose, Severson, Southey, Staines, Stewart, Travis, Weiderpass, Weinstein, Zheng, Chanock, Chatterjee, Rothman, Birmann, Cerhan and Berndt. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

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