Genomic and microenvironmental landscape of stage I follicular lymphoma, compared to stage III/IV.

G. Tjitske Los-de Vries; Wendy B.C. Stevens; Erik van Dijk; Carole Langois-Jacques; Andrew J. Clear; Phylicia Stathi; Margaretha G.M. Roemer; Matias Mendeville; Nathalie J. Hijmering; Birgitta Sander; Andreas Rosenwald; Maria Calaminici; Eva Hoster; Wolfgang Hiddemann; Philippe Gaulard; Gilles Salles; Heike Horn; Wolfram Klapper; Luc Xerri; Catherine Burton; Reuben M. Tooze; Alexandra G. Smith; Christian Buske; David W. Scott; Yasodha Natkunam; Ranjana Advani; Laurie H. Sehn; John Raemaekers; John Gribben; Eva Kimby; Marie José Kersten; Delphine Maucort-Boulch; Bauke Ylstra; Daphne de Jong

doi:10.1182/bloodadvances.2022008355

Genomic and microenvironmental landscape of stage I follicular lymphoma, compared to stage III/IV.

G. Tjitske Los-de Vries, Wendy B.C. Stevens, Erik van Dijk, Carole Langois-Jacques, Andrew J. Clear, Phylicia Stathi, Margaretha G.M. Roemer, Matias Mendeville, Nathalie J. Hijmering, Birgitta Sander, Andreas Rosenwald, Maria Calaminici, Eva Hoster, Wolfgang Hiddemann, Philippe Gaulard, Gilles Salles, Heike Horn, Wolfram Klapper, Luc Xerri, Catherine BurtonReuben M. Tooze, Alexandra G. Smith, Christian Buske, David W. Scott, Yasodha Natkunam, Ranjana Advani, Laurie H. Sehn, John Raemaekers, John Gribben, Eva Kimby, Marie José Kersten, Delphine Maucort-Boulch, Bauke Ylstra, Daphne de Jong

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

While the genomic and immune microenvironmental landscape of follicular lymphoma (FL) has been extensively investigated, little is known regarding potential biological differences between stage I and stage III/IV disease. Using next generation sequencing (NGS) and immunohistochemistry, 82 FL nodal stage I cases were analysed and compared to 139 FL stage III/IV nodal cases. Many similarities in mutations, chromosomal copy number aberrations (CNAs) and microenvironmental cell populations were detected. However, there were also significant differences in microenvironmental and genomic features. CD8+ T-cells (p=0.02) and STAT6 mutations (FDR

Original language	English
Pages (from-to)	5482-5493
Journal	Blood Advances
Volume	6
Issue number	18
DOIs	https://doi.org/10.1182/bloodadvances.2022008355 https://doi.org/10.1182/bloodadvances.2022008355
Publication status	Published - 27 Sept 2022

Keywords

Follicular lymphoma
STAT6
stage I disease
BCL2 translocation

Access to Document

10.1182/bloodadvances.2022008355Licence: CC BY-NC-ND
10.1182/bloodadvances.2022008355Licence: CC BY-NC-ND

https://www.sciencedirect.com/science/article/pii/S2473952922004542

Cite this

Vries, G. T. L., Stevens, W. B. C., Dijk, E. V., Langois-Jacques, C., Clear, A. J., Stathi, P., Roemer, M. G. M., Mendeville, M., Hijmering, N. J., Sander, B., Rosenwald, A., Calaminici, M., Hoster, E., Hiddemann, W., Gaulard, P., Salles, G., Horn, H., Klapper, W., Xerri, L., ... Jong, D. D. (2022). Genomic and microenvironmental landscape of stage I follicular lymphoma, compared to stage III/IV. Blood Advances, 6(18), 5482-5493. https://doi.org/10.1182/bloodadvances.2022008355, https://doi.org/10.1182/bloodadvances.2022008355

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title = "Genomic and microenvironmental landscape of stage I follicular lymphoma, compared to stage III/IV.",

abstract = "While the genomic and immune microenvironmental landscape of follicular lymphoma (FL) has been extensively investigated, little is known regarding potential biological differences between stage I and stage III/IV disease. Using next generation sequencing (NGS) and immunohistochemistry, 82 FL nodal stage I cases were analysed and compared to 139 FL stage III/IV nodal cases. Many similarities in mutations, chromosomal copy number aberrations (CNAs) and microenvironmental cell populations were detected. However, there were also significant differences in microenvironmental and genomic features. CD8+ T-cells (p=0.02) and STAT6 mutations (FDR",

keywords = "Follicular lymphoma, STAT6, stage I disease, BCL2 translocation",

author = "Vries, {G. Tjitske Los-de} and Stevens, {Wendy B.C.} and Dijk, {Erik van} and Carole Langois-Jacques and Clear, {Andrew J.} and Phylicia Stathi and Roemer, {Margaretha G.M.} and Matias Mendeville and Hijmering, {Nathalie J.} and Birgitta Sander and Andreas Rosenwald and Maria Calaminici and Eva Hoster and Wolfgang Hiddemann and Philippe Gaulard and Gilles Salles and Heike Horn and Wolfram Klapper and Luc Xerri and Catherine Burton and Tooze, {Reuben M.} and Smith, {Alexandra G.} and Christian Buske and Scott, {David W.} and Yasodha Natkunam and Ranjana Advani and Sehn, {Laurie H.} and John Raemaekers and John Gribben and Eva Kimby and Kersten, {Marie Jos{\'e}} and Delphine Maucort-Boulch and Bauke Ylstra and Jong, {Daphne de}",

year = "2022",

month = sep,

day = "27",

doi = "10.1182/bloodadvances.2022008355",

language = "English",

volume = "6",

pages = "5482--5493",

journal = "Blood Advances",

issn = "2473-9529",

publisher = "American Society of Hematology",

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Vries, GTL, Stevens, WBC, Dijk, EV, Langois-Jacques, C, Clear, AJ, Stathi, P, Roemer, MGM, Mendeville, M, Hijmering, NJ, Sander, B, Rosenwald, A, Calaminici, M, Hoster, E, Hiddemann, W, Gaulard, P, Salles, G, Horn, H, Klapper, W, Xerri, L, Burton, C, Tooze, RM, Smith, AG, Buske, C, Scott, DW, Natkunam, Y, Advani, R, Sehn, LH, Raemaekers, J, Gribben, J, Kimby, E, Kersten, MJ, Maucort-Boulch, D, Ylstra, B & Jong, DD 2022, 'Genomic and microenvironmental landscape of stage I follicular lymphoma, compared to stage III/IV.', Blood Advances, vol. 6, no. 18, pp. 5482-5493. https://doi.org/10.1182/bloodadvances.2022008355, https://doi.org/10.1182/bloodadvances.2022008355

TY - JOUR

T1 - Genomic and microenvironmental landscape of stage I follicular lymphoma, compared to stage III/IV.

AU - Vries, G. Tjitske Los-de

AU - Stevens, Wendy B.C.

AU - Dijk, Erik van

AU - Langois-Jacques, Carole

AU - Clear, Andrew J.

AU - Stathi, Phylicia

AU - Roemer, Margaretha G.M.

AU - Mendeville, Matias

AU - Hijmering, Nathalie J.

AU - Sander, Birgitta

AU - Rosenwald, Andreas

AU - Calaminici, Maria

AU - Hoster, Eva

AU - Hiddemann, Wolfgang

AU - Gaulard, Philippe

AU - Salles, Gilles

AU - Horn, Heike

AU - Klapper, Wolfram

AU - Xerri, Luc

AU - Burton, Catherine

AU - Tooze, Reuben M.

AU - Smith, Alexandra G.

AU - Buske, Christian

AU - Scott, David W.

AU - Natkunam, Yasodha

AU - Advani, Ranjana

AU - Sehn, Laurie H.

AU - Raemaekers, John

AU - Gribben, John

AU - Kimby, Eva

AU - Kersten, Marie José

AU - Maucort-Boulch, Delphine

AU - Ylstra, Bauke

AU - Jong, Daphne de

PY - 2022/9/27

Y1 - 2022/9/27

N2 - While the genomic and immune microenvironmental landscape of follicular lymphoma (FL) has been extensively investigated, little is known regarding potential biological differences between stage I and stage III/IV disease. Using next generation sequencing (NGS) and immunohistochemistry, 82 FL nodal stage I cases were analysed and compared to 139 FL stage III/IV nodal cases. Many similarities in mutations, chromosomal copy number aberrations (CNAs) and microenvironmental cell populations were detected. However, there were also significant differences in microenvironmental and genomic features. CD8+ T-cells (p=0.02) and STAT6 mutations (FDR

AB - While the genomic and immune microenvironmental landscape of follicular lymphoma (FL) has been extensively investigated, little is known regarding potential biological differences between stage I and stage III/IV disease. Using next generation sequencing (NGS) and immunohistochemistry, 82 FL nodal stage I cases were analysed and compared to 139 FL stage III/IV nodal cases. Many similarities in mutations, chromosomal copy number aberrations (CNAs) and microenvironmental cell populations were detected. However, there were also significant differences in microenvironmental and genomic features. CD8+ T-cells (p=0.02) and STAT6 mutations (FDR

KW - Follicular lymphoma

KW - STAT6

KW - stage I disease

KW - BCL2 translocation

U2 - 10.1182/bloodadvances.2022008355

DO - 10.1182/bloodadvances.2022008355

M3 - Article

SN - 2473-9529

VL - 6

SP - 5482

EP - 5493

JO - Blood Advances

JF - Blood Advances

IS - 18

ER -