Genomic evidence for complementary purine metabolism in the pea aphid, Acyrthosiphon pisum, and its symbiotic bacterium Buchnera aphidicola

TY - JOUR

T1 - Genomic evidence for complementary purine metabolism in the pea aphid, Acyrthosiphon pisum, and its symbiotic bacterium Buchnera aphidicola

AU - Ramsey, J. S.

AU - MacDonald, S. J.

AU - Jander, G.

AU - Nakabachi, A.

AU - Thomas, G. H.

AU - Douglas, A. E.

PY - 2010/3/10

Y1 - 2010/3/10

N2 - The purine salvage pathway recycles purines to nucleotides, promoting efficient utilization of purine nucleotides. Exceptionally among animals with completely sequenced genomes, the pea aphid lacks key purine recycling genes that code for purine nucleoside phosphorylase and adenosine deaminase, indicating that the aphid can neither metabolize nucleosides to the corresponding purines, nor adenosine to inosine. Purine metabolism genes in the symbiotic bacterium Buchnera complement aphid genes, and Buchnera can meet its nucleotide requirement from aphid-derived guanosine. Buchnera demand for nucleosides may have relaxed the selection for purine recycling in the aphid, leading to the loss of key aphid purine salvage genes. Further, the coupled purine metabolism of aphid and Buchnera could contribute to the dependence of the pea aphid on this symbiosis.

AB - The purine salvage pathway recycles purines to nucleotides, promoting efficient utilization of purine nucleotides. Exceptionally among animals with completely sequenced genomes, the pea aphid lacks key purine recycling genes that code for purine nucleoside phosphorylase and adenosine deaminase, indicating that the aphid can neither metabolize nucleosides to the corresponding purines, nor adenosine to inosine. Purine metabolism genes in the symbiotic bacterium Buchnera complement aphid genes, and Buchnera can meet its nucleotide requirement from aphid-derived guanosine. Buchnera demand for nucleosides may have relaxed the selection for purine recycling in the aphid, leading to the loss of key aphid purine salvage genes. Further, the coupled purine metabolism of aphid and Buchnera could contribute to the dependence of the pea aphid on this symbiosis.

KW - Acyrthosiphon pisum

KW - Buchnera aphidicola

KW - insect

KW - nucleotide synthesis

KW - purine salvage

KW - pea aphid

KW - symbiosis

KW - POLYAMINE COMPOSITION

KW - NITROGEN

KW - EXCRETION

KW - INSECT

KW - PHOSPHORIBOSYLTRANSFERASE

KW - EXPRESSION

KW - STRESS

KW - ACID

KW - GENE

UR - http://www.scopus.com/inward/record.url?scp=77955748621&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2583.2009.00945.x

DO - 10.1111/j.1365-2583.2009.00945.x

M3 - Article

SN - 0965-1748

VL - 19

SP - 241

EP - 248

JO - Insect Biochemistry and Molecular Biology

JF - Insect Biochemistry and Molecular Biology

IS - SUPPL. 2

ER -