Genomic evidence of widespread admixture from polar bears into brown bears during the last ice age

By the same authors

Screening archaeological bone for palaeogenetic and palaeoproteomic studies
Kontopoulos, I., Penkman, K., Mullin, V. E., Winkelbach, L., Unterländer, M., Scheu, A., Kreutzer, S., Hansen, H. B., Margaryan, A., Teasdale, M. D., Gehlen, B., Street, M., Lynnerup, N., Liritzis, I., Sampson, A., Papageorgopoulou, C., Allentoft, M. E., Burger, J., Bradley, D. G. & Collins, M. J., 25 Jun 2020
Article in PLoS ONE
Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent
Verdugo, M. P., Mullin, V. E., Scheu, A., Mattiangeli, V., Daly, K. G., Maisano Delser, P., Hare, A. J., Burger, J., Collins, M. J., Kehati, R., Hesse, P., Fulton, D., Sauer, E. W., Mohaseb, F. A., Davoudi, H., Khazaeli, R., Lhuillier, J., Rapin, C., Ebrahimi, S., Khasanov, M. & 21 others, Vahidi, S. M. F., MacHugh, D. E., Ertuğrul, O., Koukouli-Chrysanthaki, C., Sampson, A., Kazantzis, G., Kontopoulos, I., Bulatovic, J., Stojanović, I., Mikdad, A., Benecke, N., Linstädter, J., Sablin, M., Bendrey, R., Gourichon, L., Arbuckle, B. S., Mashkour, M., Orton, D., Horwitz, L. K., Teasdale, M. D. & Bradley, D. G., 12 Jul 2019
Article in Science
So you want to do biocodicology? A field guide to the biological analysis of parchment
Fiddyment, S., Teasdale, M. D., Vnoucek, J., Lévêque, É., Binois, A. & Collins, M. J., 1 Jun 2019
Article in Heritage Science
Ancient goat genomes reveal mosaic domestication in the Fertile Crescent
Daly, K., Maisano Delser, P., Mullin, V., Scheu, A., Mattiangeli, V., Teasdale, M. D., Hare, A., Burger, J., Pereira Verdugo, M., Collins, M. J., Kehati, R., Erek, C. M., Bar-Oz, G., Pompanon, F., Cumer, T., Çakirlar, C., Mohaseb, A. F., Decruyenaere, D., Davoudi, H., Çevik, Ö. & 20 others, Rollefson, G., Vigne, J-D., Roya, K., Fathi, H., Beizaee Doost, S., Rahimi Sorkhani, R., Vahdati, A. A., Sauer, E. W., Azizi Kharanaghi, H., Maziar, S., Gasparian, B., Pinhasi, R., Martin, L., Orton, D. C., Arbuckle, B. S., Benecke, N., Manica, A., Kolska Horwitz, L., Mashkour, M. & Bradley, D., 6 Jul 2018
Article in Science
The York Gospels: a 1000-year biological palimpsest
Teasdale, M. D., Fiddyment, S., Vnouček, J., Mattiangeli, V., Speller, C., Binois, A., Carver, M., Dand, C., Newfield, T. P., Webb, C. C., G. Bradley, D. & Collins, M. J., 25 Oct 2017
Article in Royal Society Open Science

From the same journal

Collagen sequence analysis reveals evolutionary history of extinct West Indies Nesophontes (‘island shrews’)
Buckley, M., Harvey, V. L., Orihuela, J., Mychajliw, A. M., Keating, J., Milan, J. N. A., Lawless, C., Chamberlain, A. T., Egerton, V. M. & Manning, P. L., 4 Jun 2020
Article in Molecular Biology and Evolution
Ancestral Admixture Is the Main Determinant of Global Biodiversity in Fission Yeast
Tusso, S., Nieuwenhuis, B. P. S., Sedlazeck, F. J., Davey, J. W., Jeffares, D. C. & Wolf, J. B. W., 9 Sep 2019
Article in Molecular Biology and Evolution
Fitness Landscape of the Fission Yeast Genome
Grech, L., Jeffares, D., Sadee, C. Y., Rodriguez-Lopez, M., Bitton, D. A., Hoti, M., Biagosch, C., Aravani, D., Speekenbrink, M., Illingworth, C. J. R., Schiffer, P. H., Pidoux, A. L., Tong, P., Tallada, V. A., Allshire, R., Levin, H. L. & Bahler, J., 1 Aug 2019
Article in Molecular Biology and Evolution
Evolution of Genome Architecture in Archaea: Spontaneous Generation of a New Chromosome in Haloferax volcanii
Ausiannikava, D., Mitchell, L., Marriott, H., Smith, V., Hawkins, M., Makarova, K. S., Koonin, E. V., Nieduszynski, C. A. & Allers, T., Aug 2018
Article in Molecular Biology and Evolution

Research output: Contribution to journal › Article › peer-review

Standard

Genomic evidence of widespread admixture from polar bears into brown bears during the last ice age. / Cahill, James A; Heintzman, Peter D; Harris, Kelley; Teasdale, Matthew D; Kapp, Joshua; Soares, André E Rodrigues; Stirling, Ian; Bradley, Daniel; Edwards, Ceiridwen J; Graim, Kiley; Kisleika, Aliaksandr A; Malev, Alexander V; Monaghan, Nigel; Green, Richard E.; Shapiro, Beth.

In: Molecular Biology and Evolution, 20.02.2018.

Research output: Contribution to journal › Article › peer-review

Harvard

Cahill, JA, Heintzman, PD, Harris, K, Teasdale, MD, Kapp, J, Soares, AER, Stirling, I, Bradley, D, Edwards, CJ, Graim, K, Kisleika, AA, Malev, AV, Monaghan, N, Green, RE & Shapiro, B 2018, 'Genomic evidence of widespread admixture from polar bears into brown bears during the last ice age', Molecular Biology and Evolution. https://doi.org/10.1093/molbev/msy018

APA

Cahill, J. A., Heintzman, P. D., Harris, K., Teasdale, M. D., Kapp, J., Soares, A. E. R., Stirling, I., Bradley, D., Edwards, C. J., Graim, K., Kisleika, A. A., Malev, A. V., Monaghan, N., Green, R. E., & Shapiro, B. (2018). Genomic evidence of widespread admixture from polar bears into brown bears during the last ice age. Molecular Biology and Evolution. https://doi.org/10.1093/molbev/msy018

Vancouver

Cahill JA, Heintzman PD, Harris K, Teasdale MD, Kapp J, Soares AER et al. Genomic evidence of widespread admixture from polar bears into brown bears during the last ice age. Molecular Biology and Evolution. 2018 Feb 20. https://doi.org/10.1093/molbev/msy018

Author

Cahill, James A ; Heintzman, Peter D ; Harris, Kelley ; Teasdale, Matthew D ; Kapp, Joshua ; Soares, André E Rodrigues ; Stirling, Ian ; Bradley, Daniel ; Edwards, Ceiridwen J ; Graim, Kiley ; Kisleika, Aliaksandr A ; Malev, Alexander V ; Monaghan, Nigel ; Green, Richard E. ; Shapiro, Beth. / Genomic evidence of widespread admixture from polar bears into brown bears during the last ice age. In: Molecular Biology and Evolution. 2018.

Bibtex - Download

@article{6f6692722cdb468ab95c7cedbe21d0ee,

title = "Genomic evidence of widespread admixture from polar bears into brown bears during the last ice age",

abstract = "Recent genomic analyses have provided substantial evidence for past periods of gene flow from polar bears (Ursus maritimus) into Alaskan brown bears (Ursus arctos), with some analyses suggesting a link between climate change and genomic introgression. However, because it has mainly been possible to sample bears from the present day, the timing, frequency, and evolutionary significance of this admixture remains unknown. Here, we analyze genomic DNA from three additional and geographically distinct brown bear populations, including two that lived temporally close to the peak of the last ice age. We find evidence of admixture in all three populations, suggesting that admixture between these species has been common in their recent evolutionary history. In addition, analyses of ten fossil bears from the now-extinct Irish population indicate that admixture peaked during the last ice age, when brown bear and polar bear ranges overlapped. Following this peak, the proportion of polar bear ancestry in Irish brown bears declined rapidly until their extinction. Our results support a model in which ice age climate change created geographically widespread conditions conducive to admixture between polar bears and brown bears, as is again occurring today. We postulate that this model will be informative for many admixing species pairs impacted by climate change. Our results highlight the power of paleogenomics to reveal patterns of evolutionary change that are otherwise masked in contemporary data.",

keywords = "Journal Article",

author = "Cahill, {James A} and Heintzman, {Peter D} and Kelley Harris and Teasdale, {Matthew D} and Joshua Kapp and Soares, {Andr{\'e} E Rodrigues} and Ian Stirling and Daniel Bradley and Edwards, {Ceiridwen J} and Kiley Graim and Kisleika, {Aliaksandr A} and Malev, {Alexander V} and Nigel Monaghan and Green, {Richard E.} and Beth Shapiro",

note = "{\textcopyright} The Author 2018. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.This is an author-produced version of the published paper. Uploaded in accordance with the publisher{\textquoteright}s self-archiving policy. Further copying may not be permitted; contact the publisher for details",

year = "2018",

month = feb,

day = "20",

doi = "10.1093/molbev/msy018",

language = "English",

journal = "Molecular Biology and Evolution",

issn = "0737-4038",

publisher = "Oxford University Press",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Genomic evidence of widespread admixture from polar bears into brown bears during the last ice age

AU - Cahill, James A

AU - Heintzman, Peter D

AU - Harris, Kelley

AU - Teasdale, Matthew D

AU - Kapp, Joshua

AU - Soares, André E Rodrigues

AU - Stirling, Ian

AU - Bradley, Daniel

AU - Edwards, Ceiridwen J

AU - Graim, Kiley

AU - Kisleika, Aliaksandr A

AU - Malev, Alexander V

AU - Monaghan, Nigel

AU - Green, Richard E.

AU - Shapiro, Beth

N1 - © The Author 2018. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

PY - 2018/2/20

Y1 - 2018/2/20

N2 - Recent genomic analyses have provided substantial evidence for past periods of gene flow from polar bears (Ursus maritimus) into Alaskan brown bears (Ursus arctos), with some analyses suggesting a link between climate change and genomic introgression. However, because it has mainly been possible to sample bears from the present day, the timing, frequency, and evolutionary significance of this admixture remains unknown. Here, we analyze genomic DNA from three additional and geographically distinct brown bear populations, including two that lived temporally close to the peak of the last ice age. We find evidence of admixture in all three populations, suggesting that admixture between these species has been common in their recent evolutionary history. In addition, analyses of ten fossil bears from the now-extinct Irish population indicate that admixture peaked during the last ice age, when brown bear and polar bear ranges overlapped. Following this peak, the proportion of polar bear ancestry in Irish brown bears declined rapidly until their extinction. Our results support a model in which ice age climate change created geographically widespread conditions conducive to admixture between polar bears and brown bears, as is again occurring today. We postulate that this model will be informative for many admixing species pairs impacted by climate change. Our results highlight the power of paleogenomics to reveal patterns of evolutionary change that are otherwise masked in contemporary data.

AB - Recent genomic analyses have provided substantial evidence for past periods of gene flow from polar bears (Ursus maritimus) into Alaskan brown bears (Ursus arctos), with some analyses suggesting a link between climate change and genomic introgression. However, because it has mainly been possible to sample bears from the present day, the timing, frequency, and evolutionary significance of this admixture remains unknown. Here, we analyze genomic DNA from three additional and geographically distinct brown bear populations, including two that lived temporally close to the peak of the last ice age. We find evidence of admixture in all three populations, suggesting that admixture between these species has been common in their recent evolutionary history. In addition, analyses of ten fossil bears from the now-extinct Irish population indicate that admixture peaked during the last ice age, when brown bear and polar bear ranges overlapped. Following this peak, the proportion of polar bear ancestry in Irish brown bears declined rapidly until their extinction. Our results support a model in which ice age climate change created geographically widespread conditions conducive to admixture between polar bears and brown bears, as is again occurring today. We postulate that this model will be informative for many admixing species pairs impacted by climate change. Our results highlight the power of paleogenomics to reveal patterns of evolutionary change that are otherwise masked in contemporary data.

KW - Journal Article

U2 - 10.1093/molbev/msy018

DO - 10.1093/molbev/msy018

M3 - Article

C2 - 29471451

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 0737-4038

ER -

York staff: edit these data

The York Research Database

By the same authors

From the same journal