By the same authors

From the same journal

Genomic prediction of cognitive traits in childhood and adolescence

Research output: Contribution to journalArticlepeer-review

Author(s)

  • A. G. Allegrini
  • S. Selzam
  • K. Rimfeld
  • S. von Stumm
  • J. B. Pingault
  • R. Plomin

Department/unit(s)

Publication details

JournalMolecular psychiatry
DateAccepted/In press - 14 Feb 2019
DateE-pub ahead of print - 11 Apr 2019
DatePublished (current) - 1 Jun 2019
Issue number6
Volume24
Number of pages9
Pages (from-to)819-827
Early online date11/04/19
Original languageEnglish

Abstract

Recent advances in genomics are producing powerful DNA predictors of complex traits, especially cognitive abilities. Here, we leveraged summary statistics from the most recent genome-wide association studies of intelligence and educational attainment, with highly genetically correlated traits, to build prediction models of general cognitive ability and educational achievement. To this end, we compared the performances of multi-trait genomic and polygenic scoring methods. In a representative UK sample of 7,026 children at ages 12 and 16, we show that we can now predict up to 11% of the variance in intelligence and 16% in educational achievement. We also show that predictive power increases from age 12 to age 16 and that genomic predictions do not differ for girls and boys. We found that multi-trait genomic methods were effective in boosting predictive power. Prediction accuracy varied across polygenic score approaches, however results were similar for different multi-trait and polygenic score methods. We discuss general caveats of multi-trait methods and polygenic score prediction, and conclude that polygenic scores for educational attainment and intelligence are currently the most powerful predictors in the behavioural sciences.

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