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Global low-frequency motions in protein allostery: CAP as a model system

Research output: Contribution to journalArticle

Published copy (DOI)

Author(s)

  • Philip D. Townsend
  • Thomas L. Rodgers
  • Ehmke Pohl
  • Mark R. Wilson
  • Tom C B McLeish
  • Martin J. Cann

Department/unit(s)

Publication details

JournalBiophysical Reviews
DatePublished - Jun 2015
Issue number2
Volume7
Number of pages8
Pages (from-to)175-182
Original languageEnglish

Abstract

Allostery is a fundamental process by which ligand binding to a protein alters its activity at a distant site. There is considerable evidence that allosteric cooperativity can be communicated by the modulation of protein dynamics without conformational change. The Catabolite Activator Protein (CAP) of Escherichia coli is an important experimental exemplar for entropically driven allostery. Here we discuss recent experimentally supported theoretical analysis that highlights the role of global low-frequency dynamics in allostery in CAP and identify how allostery arises as a natural consequence of changes in global low-frequency protein fluctuations on ligand binding.

    Research areas

  • Allostery, Catabolite activator protein, Dynamics, Elastic network model, Normal modes, Protein

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