By the same authors

From the same journal

Glycerol ethers as hydrotropes and their use to enhance the solubility of phenolic acids in water

Research output: Contribution to journalArticle

Published copy (DOI)


  • Bruna Soares
  • Dinis O Abranches
  • Tania E Sintra
  • Alejandro Leal-Duaso
  • Jose I. Garcia
  • Elisabet Pires
  • Seishi Shimizu
  • Simao P. Pinho
  • Joao A P Coutinho


Publication details

JournalACS Sustainable Chemistry & Engineering
DateSubmitted - 7 Feb 2020
DateAccepted/In press - 23 Mar 2020
DateE-pub ahead of print - 23 Mar 2020
DatePublished (current) - 1 Apr 2020
Issue number14
Pages (from-to)5742-5749
Early online date23/03/20
Original languageEnglish


The use of glycerol ethers (with alkyl side chain ranging from one to six methyl groups) as hydrotropes to enhance the solubility of gallic and syringic acids in water was here studied. These compounds were selected by their intrinsic interest and for serving as models for lignin fractions. The results obtained were compared against traditional co-solvents, demonstrating the exceptional hydrotropic ability of glycerol ethers. Setschenow constants show that the hydrophobicities of both solute and hydrotrope play an important role in the solubility enhancement by hydrotropy, shedding light into its molecular mechanism.

Bibliographical note

2020, ACS Publications. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations