Glycosidase mechanisms

A Vasella, G J Davies, M Bohm

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The three-dimensional structure of glycosidases and of their complexes and the study of transition-state mimics reveal structural details that correlate with mechanism, Of particular interest are the transition-state conformations harnessed by individual enzymes and the substrate distortion observed in enzyme-ligand complexes. 3D-structure in synergy with transition-state mimicry opens the way for mechanistic interpretation of enzyme inhibition and for the development of therapeutic agents.

Original languageEnglish
Pages (from-to)619-629
Number of pages11
JournalCurrent Opinion in Chemical Biology
Volume6
Issue number5
Publication statusPublished - Oct 2002

Keywords

  • GLYCOSYL-ENZYME INTERMEDIATE
  • URACIL-DNA GLYCOSYLASE
  • X-RAY CRYSTALLOGRAPHY
  • CRYSTAL-STRUCTURE
  • BETA-GLUCOSIDASE
  • CHEMOTHERAPEUTIC VALUE
  • ALPHA-MANNOSIDASE
  • AMINOCYCLOPENTITOL INHIBITORS
  • OLIGOSACCHARIDE SYNTHESIS
  • SIGNIFICANT DISCREPANCIES

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