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Glycosidase mechanisms

Research output: Contribution to journalLiterature review

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Publication details

JournalCurrent Opinion in Chemical Biology
DatePublished - Oct 2002
Issue number5
Volume6
Number of pages11
Pages (from-to)619-629
Original languageEnglish

Abstract

The three-dimensional structure of glycosidases and of their complexes and the study of transition-state mimics reveal structural details that correlate with mechanism, Of particular interest are the transition-state conformations harnessed by individual enzymes and the substrate distortion observed in enzyme-ligand complexes. 3D-structure in synergy with transition-state mimicry opens the way for mechanistic interpretation of enzyme inhibition and for the development of therapeutic agents.

    Research areas

  • GLYCOSYL-ENZYME INTERMEDIATE, URACIL-DNA GLYCOSYLASE, X-RAY CRYSTALLOGRAPHY, CRYSTAL-STRUCTURE, BETA-GLUCOSIDASE, CHEMOTHERAPEUTIC VALUE, ALPHA-MANNOSIDASE, AMINOCYCLOPENTITOL INHIBITORS, OLIGOSACCHARIDE SYNTHESIS, SIGNIFICANT DISCREPANCIES

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