Green liquid marble-based hydrogels as pesticidal pyrethrin slow-release carriers

Qin Li, Changhong Wang, Jiayuan He, Dandan Yang, Ting Li, Huixian Xu, Weifeng Shen, Liandi Zhou*, Saimeng Jin*, Qihui Zhang*, James H. Clark

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Pyrethrins are effective agents against mosquito larvae, but their rapid degradation rate in water reduces their deinsectization efficiency and increases the cost of deinsectization. Based on liquid marbles, a biodegradable slow-release hydrogel carrier is prepared using green and low-cost materials for the slow release of natural pyrethrin on water surfaces to kill mosquito larvae. Green carriers with high stability and loading of high concentrations of pyrethrin are synthesized by cross-linking Ca2+ in 5% CaCl2 solution with sodium alginate. The superior stability of liquid marbles at the water surface and the electrostatic interaction between alginate and gelatin can effectively reduce the degradation rate of pyrethrin in water. Furthermore, the carrier system displayed a long sustained-release time (>144 h) and maintained larvicidal performance after 168 h. Good floating stability is demonstrated for the liquid marble hydrogels. The larvicidal activity of the obtained drug carrier reached 100% with different water volumes but the same dosage. This work provides a strategy to exterminate mosquito larvae with high efficiency by preparing a green hydrogel drug slow-release carrier, thus providing a new approach to expanding the application of liquid marbles in green chemistry.

Original languageEnglish
Pages (from-to)3378-3387
Number of pages10
JournalGreen Chemistry
Issue number6
Publication statusPublished - 30 Jan 2024

Bibliographical note

Funding Information:
This work was financially supported by National Natural Science Foundation of China (81973451, 22208036), Fundamental and Frontier Research Fund of Chongqing (CSTB2023NSCQ-MSX0490, CSTC2019JSYJ-YZYSBAX0020, CSTC2018JCYJAX0661), the Science and Technology Research Program of Chongqing Municipal Education Commission (KJZD-K201800103), Fundamental Research Funds for the Central Universities (2019CDYGYB027, 2022CDJXY-003), Graduate Research and Innovation Foundation of Chongqing (CYS18033), Graduate Research and Innovation Project of Chongqing (CYB22041), Venture & Innovation Support Program for Chongqing Overseas Returnees (CX2019117).

Publisher Copyright:
© 2024 The Royal Society of Chemistry.

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