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Greener solvents for solid-phase synthesis

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JournalGreen Chemistry
DateAccepted/In press - 20 Dec 2016
DateE-pub ahead of print - 21 Dec 2016
DatePublished (current) - 21 Feb 2017
Issue number4
Number of pages11
Pages (from-to)952-962
Early online date21/12/16
Original languageEnglish


The use of a variety of green solvents to swell a diverse range of resins used in solid-phase synthesis is investigated. Good swelling is shown to depend on the structure of the resin and the solvent. A modelling approach based on use of a training set of solvents is used to predict which green solvents will, and will not, swell a particular resin. The chemical relevance of the swelling results is confirmed by an experimental study of a solid-supported Ugi reaction carried out in green solvents.

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© The Royal Society of Chemistry 2017

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