By the same authors

From the same journal

From the same journal

Greener solvents for solid-phase synthesis

Research output: Contribution to journalArticle

Full text download(s)

Published copy (DOI)

Author(s)

Department/unit(s)

Publication details

JournalGreen Chemistry
DateAccepted/In press - 20 Dec 2016
DateE-pub ahead of print - 21 Dec 2016
DatePublished (current) - 21 Feb 2017
Issue number4
Volume19
Number of pages11
Pages (from-to)952-962
Early online date21/12/16
Original languageEnglish

Abstract

The use of a variety of green solvents to swell a diverse range of resins used in solid-phase synthesis is investigated. Good swelling is shown to depend on the structure of the resin and the solvent. A modelling approach based on use of a training set of solvents is used to predict which green solvents will, and will not, swell a particular resin. The chemical relevance of the swelling results is confirmed by an experimental study of a solid-supported Ugi reaction carried out in green solvents.

Bibliographical note

© The Royal Society of Chemistry 2017

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations