(Halogenomethyl)phenyl α-D-Glucopyranosides as enzyme-activated irreversible inhibitors of yeast α-Glucosidase and potential anti-HIV agents

Josie C. Briggs; Alan H. Haines; Richard J.K. Taylor

doi:10.1039/P19950000027

(Halogenomethyl)phenyl α-D-Glucopyranosides as enzyme-activated irreversible inhibitors of yeast α-Glucosidase and potential anti-HIV agents

Josie C. Briggs, Alan H. Haines, Richard J.K. Taylor^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A range of (halogenomethyl)phenyl α-D-glucopyranosides 2-7, prepared from corresponding methylphenyl glucosides by synthetic manipulation of the aglycone moiety, have been investigated as enzyme-activated irreversible inhibitors of yeast α-glucosidase and their anti-HIV activity measured. Compounds 5-7, which also contain a 4- or 6-nitro group in the phenyl ring of the aglycone, are much more effective inhibitors of the enzyme than are compounds 2-4 which lack this feature.

Original language	English
Pages (from-to)	27-32
Number of pages	6
Journal	Journal of the Chemical Society, Perkin Transactions 1
DOIs	https://doi.org/10.1039/P19950000027
Publication status	Published - 1 Jan 1995

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10.1039/P19950000027

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abstract = "A range of (halogenomethyl)phenyl α-D-glucopyranosides 2-7, prepared from corresponding methylphenyl glucosides by synthetic manipulation of the aglycone moiety, have been investigated as enzyme-activated irreversible inhibitors of yeast α-glucosidase and their anti-HIV activity measured. Compounds 5-7, which also contain a 4- or 6-nitro group in the phenyl ring of the aglycone, are much more effective inhibitors of the enzyme than are compounds 2-4 which lack this feature.",

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AU - Haines, Alan H.

AU - Taylor, Richard J.K.

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AB - A range of (halogenomethyl)phenyl α-D-glucopyranosides 2-7, prepared from corresponding methylphenyl glucosides by synthetic manipulation of the aglycone moiety, have been investigated as enzyme-activated irreversible inhibitors of yeast α-glucosidase and their anti-HIV activity measured. Compounds 5-7, which also contain a 4- or 6-nitro group in the phenyl ring of the aglycone, are much more effective inhibitors of the enzyme than are compounds 2-4 which lack this feature.

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JF - Journal of the Chemical Society, Perkin Transactions 1

ER -

(Halogenomethyl)phenyl α-D-Glucopyranosides as enzyme-activated irreversible inhibitors of yeast α-Glucosidase and potential anti-HIV agents

Abstract

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