(HALOGENOMETHYL)PHENYL ALPHA-D-GLUCOPYRANOSIDES AS ENZYME-ACTIVATED IRREVERSIBLE INHIBITORS OF YEAST ALPHA-GLUCOSIDASE AND POTENTIAL ANTI-HIV AGENTS

J C  BRIGGS; A H  HAINES; R J K  TAYLOR

(HALOGENOMETHYL)PHENYL ALPHA-D-GLUCOPYRANOSIDES AS ENZYME-ACTIVATED IRREVERSIBLE INHIBITORS OF YEAST ALPHA-GLUCOSIDASE AND POTENTIAL ANTI-HIV AGENTS

J C BRIGGS, A H HAINES, R J K TAYLOR

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A range of (halogenomethyl)phenyl alpha-D-glucopyranosides 2-7, prepared from corresponding methylphenyl glucosides by synthetic manipulation of the aglycone moiety, have been investigated as enzyme-activated irreversible inhibitors of yeast alpha-glucosidase and their anti-HIV activity measured. Compounds 5-7, which also contain a 4- or 6-nitro group in the phenyl ring of the aglycone, are much more effective inhibitors of the enzyme than are compounds 2-4 which lack this feature.

Original language	English
Pages (from-to)	27-32
Number of pages	6
Journal	Journal of the Chemical Society-Perkin Transactions 1
Issue number	1
Publication status	Published - 7 Jan 1995

Keywords

BETA-GLUCOSIDASE
CHEMISTRY

Cite this

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title = "(HALOGENOMETHYL)PHENYL ALPHA-D-GLUCOPYRANOSIDES AS ENZYME-ACTIVATED IRREVERSIBLE INHIBITORS OF YEAST ALPHA-GLUCOSIDASE AND POTENTIAL ANTI-HIV AGENTS",

abstract = "A range of (halogenomethyl)phenyl alpha-D-glucopyranosides 2-7, prepared from corresponding methylphenyl glucosides by synthetic manipulation of the aglycone moiety, have been investigated as enzyme-activated irreversible inhibitors of yeast alpha-glucosidase and their anti-HIV activity measured. Compounds 5-7, which also contain a 4- or 6-nitro group in the phenyl ring of the aglycone, are much more effective inhibitors of the enzyme than are compounds 2-4 which lack this feature.",

keywords = "BETA-GLUCOSIDASE, CHEMISTRY",

author = "BRIGGS, {J C} and HAINES, {A H} and TAYLOR, {R J K}",

year = "1995",

month = jan,

day = "7",

language = "English",

pages = "27--32",

journal = "Journal of the Chemical Society-Perkin Transactions 1",

issn = "0300-922X",

publisher = "Chemical Society",

number = "1",

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T1 - (HALOGENOMETHYL)PHENYL ALPHA-D-GLUCOPYRANOSIDES AS ENZYME-ACTIVATED IRREVERSIBLE INHIBITORS OF YEAST ALPHA-GLUCOSIDASE AND POTENTIAL ANTI-HIV AGENTS

AU - BRIGGS, J C

AU - HAINES, A H

AU - TAYLOR, R J K

PY - 1995/1/7

Y1 - 1995/1/7

N2 - A range of (halogenomethyl)phenyl alpha-D-glucopyranosides 2-7, prepared from corresponding methylphenyl glucosides by synthetic manipulation of the aglycone moiety, have been investigated as enzyme-activated irreversible inhibitors of yeast alpha-glucosidase and their anti-HIV activity measured. Compounds 5-7, which also contain a 4- or 6-nitro group in the phenyl ring of the aglycone, are much more effective inhibitors of the enzyme than are compounds 2-4 which lack this feature.

AB - A range of (halogenomethyl)phenyl alpha-D-glucopyranosides 2-7, prepared from corresponding methylphenyl glucosides by synthetic manipulation of the aglycone moiety, have been investigated as enzyme-activated irreversible inhibitors of yeast alpha-glucosidase and their anti-HIV activity measured. Compounds 5-7, which also contain a 4- or 6-nitro group in the phenyl ring of the aglycone, are much more effective inhibitors of the enzyme than are compounds 2-4 which lack this feature.

KW - BETA-GLUCOSIDASE

KW - CHEMISTRY

M3 - Article

SN - 0300-922X

SP - 27

EP - 32

JO - Journal of the Chemical Society-Perkin Transactions 1

JF - Journal of the Chemical Society-Perkin Transactions 1

IS - 1

ER -