A range of (halogenomethyl)phenyl alpha-D-glucopyranosides 2-7, prepared from corresponding methylphenyl glucosides by synthetic manipulation of the aglycone moiety, have been investigated as enzyme-activated irreversible inhibitors of yeast alpha-glucosidase and their anti-HIV activity measured. Compounds 5-7, which also contain a 4- or 6-nitro group in the phenyl ring of the aglycone, are much more effective inhibitors of the enzyme than are compounds 2-4 which lack this feature.
|Number of pages||6|
|Journal||Journal of the Chemical Society-Perkin Transactions 1|
|Publication status||Published - 7 Jan 1995|