By the same authors

From the same journal

(HALOGENOMETHYL)PHENYL ALPHA-D-GLUCOPYRANOSIDES AS ENZYME-ACTIVATED IRREVERSIBLE INHIBITORS OF YEAST ALPHA-GLUCOSIDASE AND POTENTIAL ANTI-HIV AGENTS

Research output: Contribution to journalArticle

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JournalJournal of the Chemical Society-Perkin Transactions 1
DatePublished - 7 Jan 1995
Issue number1
Number of pages6
Pages (from-to)27-32
Original languageEnglish

Abstract

A range of (halogenomethyl)phenyl alpha-D-glucopyranosides 2-7, prepared from corresponding methylphenyl glucosides by synthetic manipulation of the aglycone moiety, have been investigated as enzyme-activated irreversible inhibitors of yeast alpha-glucosidase and their anti-HIV activity measured. Compounds 5-7, which also contain a 4- or 6-nitro group in the phenyl ring of the aglycone, are much more effective inhibitors of the enzyme than are compounds 2-4 which lack this feature.

    Research areas

  • BETA-GLUCOSIDASE, CHEMISTRY

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