By the same authors

Health-related quality of life in a randomized trial of antiretroviral therapy for advanced HIV disease

Research output: Contribution to journalArticle

Published copy (DOI)


  • V. R. Joyce
  • P. G. Barnett
  • A. M. Bayoumi
  • S. C. Griffin
  • T. C. Kyriakides
  • W. Yu
  • Vandana Sundaram
  • M. Holodniy
  • Sheldon Brown
  • W. Cameron
  • M. Youle
  • M. Sculpher
  • A. H. Anis
  • D. K. Owens


Publication details

JournalJ Acquir Immune Defic Syndr
DatePublished - 1 Jan 2009
Issue number1
Number of pages10
Pages (from-to)27-36
Original languageEnglish


OBJECTIVE: To assess and compare alternative approaches of measuring preference-based health-related quality of life (HRQoL) in treatment-experienced HIV patients and evaluate their association with health status and clinical variables. DESIGN: Cross-sectional study. SETTING: Twenty-eight Veterans Affairs hospitals in the United States, 13 hospitals in Canada, and 8 hospitals in the United Kingdom. PATIENTS: Three hundred sixty-eight treatment-experienced HIV-infected patients enrolled in the Options in Management with Antiretrovirals randomized trial. MEASUREMENTS: Baseline sociodemographic and clinical indicators and baseline HRQoL using the Medical Outcome Study HIV Health Survey (MOS-HIV), the EQ-5D, the EQ-5D visual analog scale (EQ-5D VAS), the Health Utilities Index Mark 3 (HUI3), and standard gamble (SG) and time trade-off (TTO) techniques. RESULTS: The mean (SD) baseline HRQoL scores were as follows: MOS-HIV physical health summary score 41.70 (11.16), MOS-HIV mental health summary score 44.76 (11.38), EQ-5D 0.77 (0.19), HUI3 0.59 (0.32), EQ-5D VAS 65.94 (21.71), SG 0.75 (0.29), and TTO 0.80 (0.31). Correlations between MOS-HIV summary scores and EQ-5D, EQ-5D VAS, and HUI3 ranged from 0.60 to 0.70; the correlation between EQ-5D and HUI3 was 0.73; and the correlation between SG and TTO was 0.43. Preference-based HRQoL scores were related to physical, mental, social, and overall health as measured by MOS-HIV. Concomitant medication use, CD4 cell count, and HIV viral load were related to some instruments' scores. CONCLUSIONS: On average, preference-based HRQoL for treatment-experienced HIV patients was decreased relative to national norms but also highly variable. Health status and clinical variables were related to HRQoL.

Bibliographical note

Joyce, Vilija R Barnett, Paul G Bayoumi, Ahmed M Griffin, Susan C Kyriakides, Tassos C Yu, Wei Sundaram, Vandana Holodniy, Mark Brown, Sheldon T Cameron, William Youle, Mike Sculpher, Mark Anis, Aslam H Owens, Douglas K Medical Research Council/United Kingdom 1999 J Acquir Immune Defic Syndr. 2009 Jan 1;50(1):27-36.

    Research areas

  • Adult , Anti-HIV Agents/*therapeutic use , Canada , Cross-Sectional Studies , Female , Great Britain , HIV Infections/*drug therapy/psychology , Humans , Male , Middle Aged, *Quality of Life, Questionnaires , Socioeconomic Factors, United States

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