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Heparin versus DNA: Chiral preferences in polyanion binding to self-assembled multivalent (SAMul) nanostructures

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JournalJournal of the American Chemical Society
DatePublished - 19 Aug 2015
Issue number32
Volume137
Number of pages4
Pages (from-to)10056-10059
Original languageEnglish

Abstract

This communication presents simple cationic self-assembling multivalent (SAMul) first generation dendrons based on l or d lysine, which form identical nanoscale assemblies in terms of dimensions and charge densities but toward which DNA and heparin exhibit different chiral binding preferences. However, higher generation dendrons with larger hydrophilic head groups are bound identically by these polyanions, irrespective of chirality. We propose that well-organized chiral ligands on the surface of self-assembled nanostructures can exhibit enantioselective polyanion binding. This demonstrates that small structural changes can be amplified by self-assembly and impact on nanoscale binding.

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© American Chemical Society 2015. This content is made available by the publisher under a Creative Commons CC BY Licence

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