Hepatitis B vaccination induces mucosal antibody responses in the female genital tract, indicating potential mechanisms of protection against infection

Samuel J. Simpson, Rebecca Wiggins, James Martin Fox, Jabu Mthethwa, Chun Cai, Charles John Nash Lacey

Research output: Contribution to journalArticlepeer-review

Abstract

Vaccines against hepatitis B virus confer effective protection. ELISA was developed to test for specific antibodies in female genital tract secretions. Anti-HBs IgG and IgA were detected in the cervico-vaginal secretions of women following Hepatitis B vaccination, indicating a potential genital tract role for neutralising antibodies against sexually transmitted HBV.
Original languageEnglish
JournalSexually transmitted diseases
Early online date16 Nov 2018
DOIs
Publication statusE-pub ahead of print - 16 Nov 2018

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