High-affinity multivalent DNA binding by using low-molecular-weight dendrons

M.A. Kostiainen; J.G. Hardy; D.K. Smith

doi:10.1002/anie.200500066

High-affinity multivalent DNA binding by using low-molecular-weight dendrons

M.A. Kostiainen, J.G. Hardy, D.K. Smith

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Nine spermines are better than one: Compound G2 exhibits high-affinity, salt-independent DNA binding as a consequence of the spermine array on its surface. Comparison with smaller dendrons and model compounds indicates a clear multivalency effect on binding.

Original language	English
Pages (from-to)	2556-2559
Number of pages	4
Journal	Angewandte Chemie International Edition
Volume	44
Issue number	17
DOIs	https://doi.org/10.1002/anie.200500066
Publication status	Published - 22 Mar 2005

Keywords

dendrimers
DNA
multivalency
nanochemistry
self-assembly
VITRO GENE TRANSFECTION
IN-VITRO
CASCADE POLYMERS
POLYAMIDOAMINE DENDRIMERS
DENDRITIC MACROMOLECULES
SUPRAMOLECULAR CHEMISTRY
CATIONIC LIPIDS
PLASMID DNA
DELIVERY
SPERMINE

Access to Document

10.1002/anie.200500066

http://dx.doi.org/10.1002/anie.200500066

Cite this

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title = "High-affinity multivalent DNA binding by using low-molecular-weight dendrons",

abstract = "Nine spermines are better than one: Compound G2 exhibits high-affinity, salt-independent DNA binding as a consequence of the spermine array on its surface. Comparison with smaller dendrons and model compounds indicates a clear multivalency effect on binding.",

keywords = "dendrimers, DNA, multivalency, nanochemistry, self-assembly, VITRO GENE TRANSFECTION, IN-VITRO, CASCADE POLYMERS, POLYAMIDOAMINE DENDRIMERS, DENDRITIC MACROMOLECULES, SUPRAMOLECULAR CHEMISTRY, CATIONIC LIPIDS, PLASMID DNA, DELIVERY, SPERMINE",

author = "M.A. Kostiainen and J.G. Hardy and D.K. Smith",

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language = "English",

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AU - Hardy, J.G.

AU - Smith, D.K.

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N2 - Nine spermines are better than one: Compound G2 exhibits high-affinity, salt-independent DNA binding as a consequence of the spermine array on its surface. Comparison with smaller dendrons and model compounds indicates a clear multivalency effect on binding.

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KW - DNA

KW - multivalency

KW - nanochemistry

KW - self-assembly

KW - VITRO GENE TRANSFECTION

KW - IN-VITRO

KW - CASCADE POLYMERS

KW - POLYAMIDOAMINE DENDRIMERS

KW - DENDRITIC MACROMOLECULES

KW - SUPRAMOLECULAR CHEMISTRY

KW - CATIONIC LIPIDS

KW - PLASMID DNA

KW - DELIVERY

KW - SPERMINE

U2 - 10.1002/anie.200500066

DO - 10.1002/anie.200500066

M3 - Article

SN - 1433-7851

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JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

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