High-efficiency non-thermal plasma synthesis of imine macrocycles

Patrycja Roszkowska; Abbie M. Scholes; James L. Walsh; Timothy L. Easun; Anna G. Slater

doi:10.1039/d4re00061g

High-efficiency non-thermal plasma synthesis of imine macrocycles

Patrycja Roszkowska, Abbie M. Scholes, James L. Walsh^*, Timothy L. Easun^*, Anna G. Slater^*

^*Corresponding author for this work

Physics

Research output: Contribution to journal › Article › peer-review

Abstract

Macrocycles are candidates for wide-ranging applications, yet their synthesis can be low-yielding, poorly reproducible, and resource-intensive, limiting their use. Here, we explore the use of Non-Thermal Plasma (NTP) as an efficient method for the synthesis of imine macrocycles at the gram scale. NTP-mediated macrocyclisations consistently achieved high yields of up to 97% in reduced reaction times compared to the standard non-plasma method, and were successfully carried out with a range of different aldehyde substrates. Control experiments were performed to explore the origin of the observed improvements. The results indicate that NTP methods could be advantageous for macrocycle synthesis, particularly for substrates that are sensitive to elevated temperature, and other materials formed via imine condensation.

Original language	English
Pages (from-to)	1896-1903
Number of pages	8
Journal	Reaction Chemistry and Engineering
Volume	9
Issue number	7
DOIs	https://doi.org/10.1039/d4re00061g
Publication status	Published - 8 Apr 2024

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© 2024 The Royal Society of Chemistry.

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High-efficiency non-thermal plasma synthesis of imine macrocycles
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AU - Roszkowska, Patrycja

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AU - Slater, Anna G.

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N2 - Macrocycles are candidates for wide-ranging applications, yet their synthesis can be low-yielding, poorly reproducible, and resource-intensive, limiting their use. Here, we explore the use of Non-Thermal Plasma (NTP) as an efficient method for the synthesis of imine macrocycles at the gram scale. NTP-mediated macrocyclisations consistently achieved high yields of up to 97% in reduced reaction times compared to the standard non-plasma method, and were successfully carried out with a range of different aldehyde substrates. Control experiments were performed to explore the origin of the observed improvements. The results indicate that NTP methods could be advantageous for macrocycle synthesis, particularly for substrates that are sensitive to elevated temperature, and other materials formed via imine condensation.

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High-efficiency non-thermal plasma synthesis of imine macrocycles

Abstract

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