Projects per year
Abstract
OBJECTIVE: To evaluate the cost-effectiveness of high-throughput, non-invasive prenatal testing (HT-NIPT) for fetal RhD genotype to guide antenatal prophylaxis with anti-D immunoglobulin compared to routine antenatal anti-D immunoglobulin prophylaxis (RAADP).
DESIGN: Cost-effectiveness decision-analytic modelling.
SETTING: Primary care.
PARTICIPANTS: A simulated population of 100,000 RhD negative women not known to be sensitised to the RhD antigen.
METHODS: A decision tree model was used to characterise the antenatal care pathway in England and the long-term consequences of sensitisation events. The diagnostic accuracy of HT-NIPT was derived from a systematic review and bivariate meta-analysis; estimates of other inputs were derived from relevant literature sources and databases. Women in whom the HT-NIPT was positive or inconclusive continued to receive RAADP, while women with a negative result received none. Five alternative strategies in which the use of HT-NIPT may affect the existing post-partum care pathway were considered.
MAIN OUTCOME MEASURES: Costs expressed in 2015GBP and impact on health outcomes expressed in terms of quality adjusted life years (QALYs) over a lifetime.
RESULTS: The results suggested that HT-NIPT appears cost saving but also less effective than current practice, irrespective of the post-partum strategy evaluated. A post-partum strategy in which inconclusive test results are distinguished from positive results performed best. HT-NIPT is only cost-effective when the overall test cost is £26.60 or less.
CONCLUSIONS: HT-NIPT would reduce unnecessary treatment with routine anti-D immunoglobulin and is cost saving when compared to current practice. The extent of any savings and cost-effectiveness is sensitive to the overall test cost. This article is protected by copyright. All rights reserved.
| Original language | English |
|---|---|
| Journal | BJOG : an international journal of obstetrics and gynaecology |
| Early online date | 7 Feb 2018 |
| DOIs | |
| Publication status | E-pub ahead of print - 7 Feb 2018 |
Bibliographical note
This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for detailsKeywords
- Journal Article
Projects
- 1 Finished
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NETSCC: TARS - Production of Technology Assessment Reviews for the NIHR
Stewart, L. (Principal investigator), Bojke, L. (Co-investigator), Craig, D. (Co-investigator), Eastwood, A. J. (Co-investigator), Griffin, S. (Co-investigator), Higgins, J. P. T. (Co-investigator), Palmer, S. J. (Co-investigator), Rothery, C. (Co-investigator), Sculpher, M. (Co-investigator), Soares, M. O. (Co-investigator), Spackman, E. (Co-investigator), Walker, S. M. (Co-investigator), Woods, B. (Co-investigator) & Woolacott, N. F. (Co-investigator)
1/04/16 → 31/03/22
Project: Research project (funded) › Research