Human and simian immunodeficiency viruses: virus-receptor interactions

N Signoret; P Poignard; D Blanc; Q J Sattentau

Human and simian immunodeficiency viruses: virus-receptor interactions

N Signoret, P Poignard, D Blanc, Q J Sattentau

The Hull York Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

The major cellular receptor for the primate immunodeficiency viruses is the CD4 molecule. As well as mediating virion attachment to the cell surface, CD4 is thought to activate the viral fusion pathway. CD4 is not, however, sufficient for viral entry; other molecules are probably involved, and in certain circumstances these may substitute for CD4. Viral tropism and cytopathogenicity are also influenced by receptor interactions.

Original language	English
Pages (from-to)	328-333
Number of pages	6
Journal	Trends in microbiology
Volume	1
Issue number	9
Publication status	Published - Dec 1993

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http://www.sciencedirect.com/science/article/pii/0966842X9390072Y

Cite this

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title = "Human and simian immunodeficiency viruses: virus-receptor interactions",

abstract = "The major cellular receptor for the primate immunodeficiency viruses is the CD4 molecule. As well as mediating virion attachment to the cell surface, CD4 is thought to activate the viral fusion pathway. CD4 is not, however, sufficient for viral entry; other molecules are probably involved, and in certain circumstances these may substitute for CD4. Viral tropism and cytopathogenicity are also influenced by receptor interactions.",

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AB - The major cellular receptor for the primate immunodeficiency viruses is the CD4 molecule. As well as mediating virion attachment to the cell surface, CD4 is thought to activate the viral fusion pathway. CD4 is not, however, sufficient for viral entry; other molecules are probably involved, and in certain circumstances these may substitute for CD4. Viral tropism and cytopathogenicity are also influenced by receptor interactions.

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